Serum/plasma miRNA marker related to type 2 diabetic retinopathy and use thereof

Abstract

The present invention provides a serum / plasma miRNA marker related to type 2 diabetic retinopathy and use thereof. The serum / plasma miRNA marker related to the type 2 diabetic retinopathy is one or a combination of two of hsa-let-7a-5p, hsa-miR-novel-chr5_15976, hsa-miR-28-3p, has-miR-20a-5p, has-miR-151a-5p, has-miR-148a-3p and has-miR-223s-3p. The serum / plasma miRNA marker related to the type 2 diabetic retinopathy is stable and can be used to early assist to diagnose whether a diabetic patient is combined with DR, and the disease progression of the diabetic retinopathy patient can be dynamically monitored, and the serum / plasma miRNA marker can be used to prepare an early diagnosis product of type 2 diabetes and the diabetic retinopathy.

Description

technical field [0001] The invention belongs to the fields of genetic engineering and clinical medicine, and relates to a serum / plasma miRNA marker related to type 2 diabetic retinal degeneration and an application thereof. Background technique [0002] Diabetes mellitus is a metabolic disorder characterized by elevated blood sugar and based on insulin resistance and insufficient insulin secretion. Chronic major diseases that various countries and governments focus on prevention and control. Clinically, diabetes is divided into type 1 diabetes and type 2 diabetes; among them, type 2 diabetes accounts for more than 90% of diabetic patients. According to the 2007-2009 national epidemiological survey, the total prevalence of diabetes in the population over 20 years old in my country has reached 9.7%. What is even more shocking is that the 2010 National Diabetes Epidemiological Survey showed that the prevalence of diabetes had risen to 11.6%, and the prevalence of prediabetes ...

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