The invention relates to the technical field of rubber, in particular relates to a tire tread rubber composition and a preparation method. The tire tread rubber composition is characterized by taking 100 parts of natural rubber as reference, also comprising 5-10 parts of liquid butadiene rubber, 40-55 parts of carbon black, 5-15 parts of white carbon black, 2.5-3.0 parts of zinc oxide, 1-3 parts of stearic acid, 1-3 parts of silane coupling agent, 1-3 parts of N-(1, 3-dimethylbutyl)-N'-phenyl-p-phenylenediamine anti-aging agent, 1-2 parts of 2, 2, 4-trimethyl-1, 2-dihydroquinoline polymer anti-aging agent, 1-2 pats of protective wax, 1-1.5 parts of sulphur, 1.0-1.5 parts of vulcanization accelerator, and 0.1-0.3 parts of anti-scorching agent in part by weight. In the tire tread rubber composition, the tire wear property can be increased, the tire rolling resistance can be lowered, the tire slippery property is improved, and the comprehensive use property of the tire can be enhanced.