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Pharmaceutical composition for curing diabetic retina pathological changes and method of preparing the same

A technology for retinopathy and diabetes, which is applied in the field of compositions for treating diabetic retinopathy and its preparation, and can solve problems such as unfavorable production quality control, improvement of drug efficacy, and low purity of arctiin

Inactive Publication Date: 2008-10-01
THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] The deficiencies of the above inventions are: only the hypoglycemic effect of arctium extract is found, and the medicinal ingredients are mixtures, which is not conducive to the improvement of production quality control and drug effect; the purity of arctiin is not high

Method used

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  • Pharmaceutical composition for curing diabetic retina pathological changes and method of preparing the same
  • Pharmaceutical composition for curing diabetic retina pathological changes and method of preparing the same
  • Pharmaceutical composition for curing diabetic retina pathological changes and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Embodiment 1 Preparation method of arctiin and arctigenin

[0076] (1) Preparation of arctiin

[0077] ①Crude extraction of arctiin: crushed burdock fruit, put it in a Soxhlet extractor, reflux and degrease it with petroleum ether with a boiling range of 60-90°C for 2 times, take it out after degreasing and dry it, and extract it twice with 60% 8 times ethanol under reflux, Each time for 0.8h, the extract was concentrated under reduced pressure at 60°C to obtain a dark brown extract;

[0078] ②Macroporous resin refining: Add 15% ethanol to the dark brown extract, ultrasonically treat it for 15 minutes to make it fully dissolve, filter to a solution with a concentration of about 5 mg / mL, and pass through the AB-8 macroporous adsorption resin. The volume of the macroporous adsorption resin is 1 times that of the liquid medicine, the flow rate is controlled at 1.5BV / h, the column diameter-to-height ratio is controlled at 1:5, the volume of the resin is washed with water f...

Embodiment 2

[0083] Example 2 Preparation method of arctiin and arctigenin

[0084] (1) Preparation of arctiin

[0085] ①Crude extraction of arctiin: crushed burdock fruit, put it in a Soxhlet extractor, reflux and degrease it with petroleum ether with a boiling range of 60-90°C for 4 times, take it out and dry it after degreasing, and extract 4 times with 80% 8 times ethanol under reflux, Each time for 2 hours, the extract was concentrated under reduced pressure at 80°C to obtain a dark brown extract;

[0086] ②Macroporous resin refining: add dark brown extract with 35% ethanol, ultrasonic treatment for 35 minutes to make it fully dissolved, filter to a solution with a concentration of about 7mg / mL, pass through AB-8 macroporous adsorption resin, The volume of the macroporous adsorption resin is twice that of the liquid medicine, the flow rate is controlled at 2.5BV / h, the column diameter-to-height ratio is controlled at 1:5, the volume of the resin is three times the volume of water was...

Embodiment 3

[0091] Example 3 Preparation method of arctiin and arctigenin

[0092] (1) Preparation of arctiin

[0093] ①Crude extraction of arctiin: crushed burdock fruit, put it in a Soxhlet extractor, reflux and degrease it with petroleum ether with a boiling range of 60-90°C for 3 times, take it out after degreasing and dry it, and reflux extraction with 70% 8 times ethanol for 3 times. Each time for 1 hour, the extract was concentrated under reduced pressure at 70°C to obtain a dark brown extract;

[0094] ②Macroporous resin refining: Add 20% ethanol to the dark brown extract, ultrasonically treat it for 20 minutes to make it fully dissolved, filter it to a solution with a concentration of about 6mg / mL, pass it through the AB-8 macroporous adsorption resin, The volume of the macroporous adsorption resin is 1.5 times the volume of the liquid medicine, the flow rate is controlled at 2BV / h, the column diameter-to-height ratio is controlled at 1:5, the volume of the resin is washed 3 tim...

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Abstract

The invention relates to a composition containing 50 to 99 parts by weight of arctiin with the purity of more than 90 percent or 1 to 50 parts by weight of arctigenin and a preparation method thereof, and the functions of the composition are the treatment and the prevention of diabetic retinopathy. In the invention, by extracting the arctiin and the arctigenin, the pharmacological, toxicological and clinical trial results show that the composition of arctiin or arctigenin of the invention has the advantages of strong treatment effect and small toxicity and side effects in the treatment of the diabetic retinopathy.

Description

technical field [0001] The invention relates to a pharmaceutical composition with plant material extract as an active ingredient, in particular to a group of compositions for treating diabetic retinopathy and a preparation method thereof. Background technique [0002] At present, the incidence of diabetes in the world is about 4.6%, with a total of 200 million people. Its incidence rate is increasing year by year. It is estimated that by 2025, the incidence rate of diabetes will be about 5.4%, reaching 300 million people. [0003] Diabetic retinopathy (DR) is the most common and serious eye complication in diabetic patients, and it is one of the three major blinding diseases in the world. The rate of diabetic patients with retinopathy in my country is as high as 47% (the international average level is 45%). Diabetic retinopathy has no obvious eye symptoms in the early stage of the disease. As the disease progresses, vision loss or sudden drop may occur, and severe cases ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/365A61P27/02A61P3/10
Inventor 卢春来周世文张蓉徐梓辉黄林清邢茂应懿周吉银
Owner THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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