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Composition, preparation, method for preparing same, application and method for applying preparation

A technology of composition and preparation, applied in application, food preparation, drug combination, etc., can solve the problems of insignificant treatment effect, large toxic and side effects, and long treatment period.

Inactive Publication Date: 2015-11-25
GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, the dressing ointment and film plaster prepared by simple traditional Chinese medicine ingredients have no obvious therapeutic effect and long treatment cycle; the recurrence rate of physical therapy is high; the preparation for inhibiting fibroblast proliferation and migration has a strong cell division inhibition effect, and the The side effects are large, which may cause serious complications such as non-healing wounds; and the cost of nucleic acid drugs that synthesize anti-scarring and tissue fibrosis is high
Therefore, the prior art treatment methods for scars, especially facial scars, have the disadvantages of poor effect, inconvenient use and high cost.

Method used

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  • Composition, preparation, method for preparing same, application and method for applying preparation
  • Composition, preparation, method for preparing same, application and method for applying preparation

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preparation example Construction

[0035] The present application also provides a preparation method of the above preparation, comprising the following steps:

[0036] mixing hyaluronidase with a solvent to obtain a first preparation;

[0037] The flavonoid compound quercetin, the volatile oil of Ligusticum chuanxiong, the recombinant angiogenesis inhibitor and the solvent are mixed to obtain the second preparation.

[0038] After the preparation of the above preparations is completed, the first preparation and the second preparation are assembled into a set.

[0039] The present application also provides the application of the preparation in eliminating scars, especially facial scars. The formulations described in this application act on the surface of facial scars as injection formulations to eliminate facial scars.

[0040] The application also provides a method for using the preparation. Firstly, the first preparation is applied to the scar wound on the patient's face, and then the second preparation is app...

Embodiment 1

[0044] Hyaluronidase was added to physiological saline to prepare a solution with a concentration of 25 U / ml to obtain solution A.

[0045] Add flavonoid quercetin and Chuanqiong volatile oil to normal saline to obtain concentrations of 1 μmol / ml and 50ug / ml, respectively, and then add recombinant angiogenesis inhibitor Ad-METH-1 to prepare a concentration of 100mg / ml to obtain B solution.

[0046] Solution A and solution B are divided into injection preparations of different specifications and assembled into a set capable of eliminating facial scars.

[0047] Dosage and method of use, for scars with a size of 1cm*1cm*0.2cm, inject 0.5ml of preparation A first, and then inject 0.5ml of preparation B after 15min-30min. Since the facial scars are different, some are scattered small-volume scars, Evenly dispersed multi-point subcutaneous injection can be taken.

[0048] Twelve scar wound models were established on the ventral side of ears of 3 white rabbits, and the 12 scar wou...

Embodiment 2

[0051] Hyaluronidase was added to physiological saline to prepare a solution with a concentration of 50 U / ml to obtain solution A.

[0052] Add flavonoids quercetin and Chuanqiong volatile oil to normal saline to obtain concentrations of 10 μmol / ml and 100ug / ml, respectively, and then add recombinant angiogenesis inhibitor Ad-METH-1 to prepare a concentration of 200mg / ml to obtain B solution.

[0053] Solution A and solution B are divided into injection preparations of different specifications and assembled into a set capable of eliminating facial scars.

[0054] Dosage and method of use, for scars with a size of 1cm*1cm*0.2cm, inject 0.5ml of preparation A first, and then inject 0.5ml of preparation B after 15min-30min. Since the facial scars are different, some are scattered small-volume scars, Evenly dispersed multi-point subcutaneous injection can be taken.

[0055] Twelve scar wound models were established on the ventral side of ears of 3 white rabbits, and the 12 scar ...

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Abstract

The invention provides a composition which comprises a component A and a component B. The component A comprises hyaluronidase, and the component B comprises quercetin, volatile oil of ligusticum wallichii and recombinant angiogenesis inhibitors. The invention further provides application of the composition and a preparation. The composition can be applied to preparing cosmetics, medicine and / or healthcare products for preventing and / or repairing scar. The preparation comprises a first preparation and a second preparation. The first preparation comprises hyaluronidase and medically acceptable solvents, and the second preparation comprises volatile oil of ligusticum wallichii, quercetin recombinant angiogenesis inhibitors and medically acceptable solvents. The composition, the application and the preparation have the advantages that the components are added into the preparation, so that scar preventing effects can be realized by the preparation, and the formed scar can be treated.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to compositions, preparations, preparation methods, applications and usage methods of the preparations. Background technique [0002] Scars are also known as scars and keloids, commonly known as keloids or giant scars. A scar is a benign lump that bulges out of the normal skin, has different shapes, and is red and hard. The end result of the body's protective response to trauma. It is mainly composed of dense collagen fibrous tissue, containing a small amount of nerve endings, the fiber bundles are disorderly arranged, and the surface is covered with a layer of fragile new epithelium, which is hard in texture, lacks the elasticity, color and texture of normal skin, and has no sweat glands and sweat ducts, so it lacks due function Physiological function and normal form. Obviously, facial scars are the scars left after the wounds on the face heal, which seriously affect the appea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K38/46A61K8/96A61K8/97A61K8/66A61P17/02A23L1/30A61Q19/00A61K31/352A61K36/236
Inventor 陈海佳王一飞葛啸虎李丽娟
Owner GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
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