Combined use of angiogenesis inhibitor and taxane

A composition, alkyl technology, applied in the direction of drug combination, medical preparations containing active ingredients, organic active ingredients, etc.

Active Publication Date: 2011-04-27
EISIA R&D MANAGEMENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005]However, there is no report on whether a pharmaceutical composition composed of these substances shows an antitumor effect

Method used

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  • Combined use of angiogenesis inhibitor and taxane
  • Combined use of angiogenesis inhibitor and taxane
  • Combined use of angiogenesis inhibitor and taxane

Examples

Experimental program
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Effect test

Embodiment 1

[0294] [Example 1] Combined use of E7080 and docetaxel in a non-small cell lung cancer cell line (A549) subcutaneous transplantation model (in vivo)

[0295] The human non-small cell lung cancer cell line A549 (purchased from Dainippon Sumitomo Pharmaceutical Co., Ltd.) was cultured with RPMI1640 (containing 10% FBS) in a 5% carbon dioxide incubator at a temperature of 37 ° C to about 80% confluent, and then used Trypsin-EDTA recovered cells. Prepare 1×10 in phosphate buffer 8 cells / mL of cell suspension, and then add an equal amount of matrigel (matrigel) to prepare 5 × 10 7 cells / mL of the cell suspension, and the resulting cell suspension was subcutaneously transplanted into the side of nude mice in an amount of 0.1 mL per mouse. From day 14 after transplantation, the following substances were administered orally in single dose or in combination according to the following schedule: 4-(3-Chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7- Methoxy-6-carbamoylquinoline (her...

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Abstract

The object is to discover a pharmaceutical composition having an excellent anti-tumor effect and a therapeutic method for cancer. 4-(3-Chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7- methoxy-6-quinolinecarboxamide, an analogous compound or pharmacologically acceptable salt thereof, or a solvate of the compound or the analogous compound or pharmacologically acceptable salt can exhibit an excellent anti-tumor effect when used in combination with a taxane.

Description

technical field [0001] The present invention relates to a combination comprising a compound represented by general formula (I), or a pharmacologically acceptable salt thereof, or a solvate thereof (hereinafter also referred to as "the compound of the present invention") and taxane The pharmaceutical composition and kit, and the cancer treatment method characterized by administering an effective amount of the pharmaceutical composition to a patient, the use of the compound of the present invention in the manufacture of the above pharmaceutical composition, and the use of the above pharmaceutical composition Compounds of the present invention and the like. Background technique [0002] Substances that have been used as chemotherapeutic agents for cancer include the alkylating agent cyclophosphamide, the metabolic antagonists methotrexate, fluorouracil, the antibiotics doxorubicin, mitomycin, and bleomycin, and the plant-derived taxane Alkanes, vincristine, etoposide, metal co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D215/48A61K31/337A61K31/47A61P35/00A61P43/00
CPCA61K31/337C07D215/48A61K31/47A61P35/00A61P35/04A61P43/00A61K2300/00
Inventor 山本裕之
Owner EISIA R&D MANAGEMENT CO LTD
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