Quick detection method for Wangbi preparation dry intermediate multiple indexes
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An intermediate and drying technology, applied in the field of near-infrared detection, can solve the problems of lagging analysis results, time-consuming and laborious, and achieve the effects of shortening detection time, quality and safety, and improving production efficiency and economic benefits.
Inactive Publication Date: 2016-12-21
LIAONING HUANREN PHARMA
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At present, quality control mainly relies on experience and traditional quality analysis methods (HPLC, etc.), which are time-consuming and laborious, and the analysis results are lagging behind, so it is difficult to be widely used in production practice. The overall quality control of dry intermediates is very necessary and has development prospects
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[0048] Follow the steps below to carry out the multi-index rapid detection of the dry intermediate of Bibi preparation:
[0049] (1) Collect 88 batches of intermediate particles with different production dates and place them in dry sealed bags to obtain 88 standard products; use traditional methods to measure key quality control indicators, specifically:
[0050] 1) Determination of moisture content:
[0051] Accurately weigh 1g of the sample in a flat bottle with dry constant weight, dry it in an oven at 105°C for 5h, move it to a desiccator to cool for 30min, weigh it accurately, then dry it at the above temperature for 1h, cool down, weigh, until continuous If the difference between the two times does not exceed 5mg, calculate the moisture content;
[0052] 2) Determination of the contents of paeonifloride, paeoniflorin, 5-O-methylvisamigoside, icariin and epimedin C by HPLC:
[0053] a. Sample pretreatment: Take 1g of the sample, weigh it accurately, add 25mL of dilute e...
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Abstract
The invention relates to a quick detection method for Wangbi preparation dry intermediate multiple indexes. The method comprises the steps of: (1) determining the content of Wangbi intermediate standard preparation drying moisture, albiflorin, paeoniflorin, 5-O-methylvisammioside, icariin and Epimedin C in Wangbi preparation dry intermediate standard substances; (2) acquiring infrared diffuse reflection spectrums of the standard substances; (3) conducting pretreatment on the spectrums; (4) establishing a content prediction model by partial least square regression; (5) collecting the infrared diffuse reflection spectrum of a to-be-detected sample and performing pretreatment; and (6) substituting the pretreatment spectral data of the to-be-detected sample into the model obtained in step (4), thus acquiring predicted values of corresponding component contents. The method provided by the invention introduces the near infrared spectroscopic analysis technology into quality control of Wangbi preparation intermediates, realizes rapid determination of various quality control index contents, shortens the detection time, saves the production cost, improves the production efficiency and economic benefits, and ensures the safety and effectiveness of Wangbi tablets.
Description
technical field [0001] The invention belongs to the technical field of near-infrared detection, and in particular relates to a multi-indicator rapid detection method for dry intermediates of qibi preparations. Background technique [0002] Lunbi preparation is composed of epimedium, white peony root, rehmannia glutinosa, rehmannia glutinosa, Dipsacus, Fupian (heishun tablet), solitary living, rhizoma drynaria, cassia twig, windproof, clematis, saponin thorn, sheep bone, A compound preparation made of Gouji (made), Zhimu, Shenjincao, and safflower seventeen flavors of traditional Chinese medicine. The symptoms of numbness caused by collaterals include muscle and joint pain, local swelling, stiffness and deformity, poor flexion and extension, soreness of the waist and knees, chills and fatigue, and rheumatoid arthritis. [0003] Lubi preparations are extracted by modern extraction technology, and through a series of processes such as alcohol precipitation, concentration, dryi...
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