Ionic iridium complex coated polymer nano-particles and preparation method and application thereof

A technology of iridium complexes and nanoparticles, which is applied in the field of organic optoelectronic functional materials, can solve the problems of harm to organisms, and achieve the effects of good sensitivity, easy emission wavelength, and excellent water solubility

Inactive Publication Date: 2017-01-04
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the production of ROS is essential for life in the normal cellular environment, they

Method used

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  • Ionic iridium complex coated polymer nano-particles and preparation method and application thereof
  • Ionic iridium complex coated polymer nano-particles and preparation method and application thereof
  • Ionic iridium complex coated polymer nano-particles and preparation method and application thereof

Examples

Experimental program
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Example Embodiment

[0044] Example 1: Preparation of ionic iridium complex Ir-1:

[0045] In this embodiment, the N^N auxiliary ligand is C=N-OH-bpy, and the C^N ring metal ligand is C-12 with a long-chain alkyl group of 12 carbons. The structural formulas of the two are:

[0046]

[0047] The synthesis reaction formula of this embodiment is:

[0048]

[0049] (1) Preparation of iridium dichloride bridge: Weigh C-12 (2.2mmol) and IrCl 3 ·3H 2 O (1 mmol) was mixed and poured into a three-necked flask, and vacuum-preserved nitrogen-evacuated on the double-row tube, cyclically repeated three times, and finally protected the entire reaction system with nitrogen. A mixture of ethylene glycol ether and water with a volume ratio of 3:1 was injected into the reaction system, the temperature was raised to 110° C., and the reaction was carried out with magnetic stirring for 24 hours. After the reaction, the system is cooled to room temperature, the precipitate is filtered, and washed with ethanol and water. The ...

Example Embodiment

[0052] Example 2: Preparation of complex Ir-2:

[0053] The N^N auxiliary ligand in this embodiment is C=N-OH-bpy, the C^N ring metal ligand is C-18 with a long-chain alkyl group of 18 carbons, and the structural formula of C-18 is:

[0054]

[0055] The synthesis reaction formula of this embodiment is:

[0056]

[0057] (1) Preparation of iridium dichloride bridge: Weigh C-18 (2.2 mmol) and IrCl 3 ·3H 2 O (1 mmol) was mixed and poured into a three-necked flask, and vacuum-preserved nitrogen-evacuated on the double-row tube, cyclically repeated three times, and finally protected the entire reaction system with nitrogen. A mixture of ethylene glycol ether and water with a volume ratio of 3:1 was injected into the reaction system, the temperature was raised to 110° C., and the reaction was carried out with magnetic stirring for 24 hours. After the reaction, the system is cooled to room temperature, the precipitate is filtered, and washed with ethanol and water. The obtained solid prod...

Example Embodiment

[0060] Example 3:

[0061] This embodiment provides a polymer nanomaterial coated with an ionic iridium complex, including the amphiphilic polymer polyethylene glycol-polylactic acid and the amphiphilic polymer polyethylene glycol-polylactic acid nanoparticles Ionic iridium complex in the core. The general structure of the iridium complex is as follows:

[0062]

[0063] Among them, the structure of C^N ligand is as follows:

[0064]

[0065] Among them, R is H, CH 3 (CH 2 ) 4 CH 3 , CH 3 (CH 2 ) 10 CH 3 , CH 3 (CH 2 ) 16 CH 3 .

[0066] Take the Ir-1 prepared in Example 1 of one of the iridium complexes as an example, in which the cyclometal ligand is C-12, the auxiliary ligand is C=N-OH-bpy, and the structural formula is shown in the following molecular formula:

[0067]

[0068] The molecular weight of the polyethylene glycol-polylactic acid is 26778, and the particle size of the polyethylene glycol-polylactic acid nanoparticles coated with the ionic iridium complex is 80-110 nm. ...

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Abstract

The invention belongs to the technical field of organic photoelectric functional material and provides anionic iridium complex coated polymer nano-particles and a preparation method and application thereof. Firstly, a phosphorescent iridium complex for detecting hypochlorite (ClO-) and containing oximido groups (-C = N-OH); secondly, a ring opening polymerization method is adopted and polyethylene glycolis used as an initiator to prepare anamphiphilic polymer polyethylene glycol-polylactic acid (mPEG-PLA); finally, the iridium complex and the amphiphilic polymer perform self-assembly to obtain the ionic iridium complex coated polyethylene glycol-polylactic acid polymer nano-particles by adopting a nano precipitation method. The nano-material coated iridium complex has the following structural formula. The nano-material can be applied to the fields of hypochlorite detection, cell marking and imaging, time-resolved service life imaging and the like. The nano-particles are uniform in size, good in biocompatibility, simple to prepare, remarkable in ClO- detection effect, good in selectivity and quick to response and can be excited by visible light.

Description

technical field [0001] The invention belongs to the technical field of organic photoelectric functional materials, and specifically relates to a polyethylene glycol-polylactic acid nanoparticle coated with an ionic iridium complex and a preparation method thereof. The invention also relates to the detection of hypochlorite, Applications in cellular imaging and biomarkers. Background technique [0002] Compared with inorganic nanomaterials, polymer nanoparticles have many advantages, such as good water solubility, good biocompatibility, and biodegradability. They are often used as good carriers for hydrophobic organic materials in bioimaging and cancer treatment. middle. [0003] As we all know, reactive oxygen species (Reactive oxygen species, ROS) refers to a series of intermediate products produced during the reduction process of molecular oxygen, including highly active intermediate products that exist in the form of free radicals and that do not exist in the form of fre...

Claims

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Application Information

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IPC IPC(8): C09K11/06G01N21/64
CPCC09K11/06C09K2211/185G01N21/6408G01N21/6486G01N2021/641
Inventor 赵强黄维李世斌张寅许文娟刘淑娟郭颂
Owner NANJING UNIV OF POSTS & TELECOMM
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