A kind of Shuxuening injection prepared from ginkgo biloba composition and its preparation method

A composition and ginkgo biloba technology are applied in the field of Shuxuening injection and its preparation, which can solve the problems of low extraction rate of active components, and achieve the effects of stable curative effect, good stability and improved product quality.

Active Publication Date: 2019-04-16
HEILONGJIANG ZBD PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application uses ethanol-water solution for extraction, and the extraction rate of active ingredients is low

Method used

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  • A kind of Shuxuening injection prepared from ginkgo biloba composition and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034]Embodiment 1: Ginkgo biloba composition

[0035] 1. Extraction method

[0036] (1) Take Ginkgo biloba leaves for ultrafine grinding, add extractant, ultrasonically extract at 55°C for 0.75h, collect the extract, filter the residue and extract it with 4 times of organic solvent under reflux for 1h, and collect the extract;

[0037] (2) Combine the extracts, adjust the pH to 7.6 with NaOH solution, let stand for 20h, filter, add water to the volume of 6 times the ginkgo leaf amount;

[0038] (3) add concentrated hydrochloric acid to adjust pH to be 4.6, centrifuge at 4800r / min;

[0039] (4) The centrifuged liquid passes through the macroporous adsorption resin column with 1.7BV / h; washes the resin with the flow rate of 3.5BV / h with the purified water of 1.2BV, 15% ethanol of 1.6BV, adds the resin column with 80% ethanol of 5.5BV Soak for 1 hour, elute at a flow rate of 1.4BV / h, and collect the eluate;

[0040] (5) The eluent is concentrated under reduced pressure to obt...

Embodiment 2

[0087] Embodiment 2: Ginkgo biloba composition

[0088] 1. Extraction method

[0089] (1) Take Ginkgo biloba leaves for ultrafine grinding, add extractant, and conduct ultrasonic extraction at 50° C. for 0.5 h, collect the extract, and then use 3 times the organic solvent to reflux extract the filter residue for 0.5 h, and collect the extract;

[0090] (2) Combine the extracts, adjust the pH to 7.5 with NaOH solution, let stand for 12h, filter, add water to make it 5 times the volume of Ginkgo biloba;

[0091] (3) add concentrated hydrochloric acid to adjust pH to be 4.5, centrifuge at 4500r / min;

[0092] (4) The centrifuge passes through the macroporous adsorption resin column at 1.6BV / h; washes the resin with 15% ethanol of 1BV of purified water and 1.5BV at a flow rate of 3.0BV / h, and adds 80% ethanol of 5BV into the resin column for soaking 0.5h, eluted at a flow rate of 1.3BV / h, and collected the eluate;

[0093] (5) The eluent is concentrated under reduced pressure to...

Embodiment 3

[0102] Embodiment 3: Ginkgo biloba composition

[0103] 1. Extraction method

[0104] (1) Take Ginkgo biloba leaves for ultrafine grinding, add extractant, ultrasonically extract at 60°C for 1 hour, collect the extract, and filter the residue with 5 times of organic solvent for reflux extraction for 1.5 hours, and collect the extract;

[0105] (2) Combine the extracts, adjust the pH to 8.0 with NaOH solution, let stand for 24h, filter, add water to make it 6 times the volume of Ginkgo biloba;

[0106] (3) add concentrated hydrochloric acid to adjust the pH to be 5.0, and centrifuge at 5000r / min;

[0107] (4) The centrifuge passes through the macroporous adsorption resin column with 1.8BV / h; washes the resin with 1.5BV of purified water and 2BV of 15% ethanol at a flow rate of 4.0BV / h, and adds 80% ethanol of 6BV into the resin column for soaking 1h, eluted at a flow rate of 1.5BV / h, and collected the eluate;

[0108] (5) The eluent is concentrated under reduced pressure to ...

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Abstract

The invention relates to a ginkgo bioba composition, and particularly discloses a Shuxuening parenteral injection prepared from ginkgo bioba composition, and preparation method of the Shuxuening parental injection. The preparation method of the ginkgo bioba composition comprises the following steps of: superfinely grinding ginkgo bioba leaves, adding an extractant for ultrasonic extraction, performing reflux extraction to filter residue with an organic solvent, and collecting extracting liquid; adjusting the pH and centrifuging; leading centrifuged liquid to flow through an adsorbent resin column; flushing resin with purified water and 15% ethanol, adding 5-6BV of 80% ethanol into the resin column and soaking for 0.5-1h and eluting, and collecting eluent; performing decompressed concentration to the eluent and extracting; and adjusting the pH, performing pottery membrane ultrafiltration, concentrating, and drying to obtain the ginkgo bioba composition. The ginkgo bioba composition has high target component content, is good in purity, and the product quality can be improved. The prepared Shuxuening parenteral injection is good in stability, fewer in impurities, good in solubility and stable in efficacy.

Description

technical field [0001] The invention relates to a ginkgo leaf composition, in particular to a Shuxuening injection prepared from the ginkgo leaf composition and a preparation method thereof. Background technique [0002] Ginkgo biloba is also known as Gongsun tree, ginkgo tree, etc. Its seeds, ginkgo, have a long history in my country as a traditional Chinese medicine for relieving cough, relieving asthma, reducing stool, and stopping turbidity. Its leaves, Ginkgo biloba, also known as ginkgo leaves, are the dried leaves of Ginkgo biloba, a plant of the family Ginkgoceae. The chemical composition of Ginkgo biloba is very complex. More than 170 compounds have been found so far, mainly flavonoids, terpenes, alcohols, alkaloids, polyisoprenes, polysaccharides and other active ingredients with pharmacological effects. The toxic ingredients are Ginkgolic acid. [0003] Ginkgo biloba is a traditional Chinese medicinal material for promoting blood circulation and removing blood s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K36/16A61P11/06A61P9/10A61P3/06A61P25/24A61P3/10A61P25/00A61P25/28A61P9/14
CPCA61K9/0019A61K9/08A61K36/16A61K2236/15A61K2236/333A61K2236/35A61K2236/55
Inventor 方同华范玉奇周广红贾文娟崔玉海
Owner HEILONGJIANG ZBD PHARMA
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