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Novel homologous recombinant inhibitor

A preparation and composition technology, applied in the field of pharmaceutical compounds, can solve problems such as cell death, genome instability, and imprecise repair

Inactive Publication Date: 2017-03-01
应颂敏 +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Homologous recombination plays a major role in it, and repairs the damaged chromosome similar to it by using another undamaged chromosome as a template; the repair method of non-homologous end joining is imprecise repair, and the resulting DNA is often cause genome instability and eventually cell death

Method used

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Embodiment Construction

[0036] Through extensive and in-depth research, the present inventors unexpectedly found for the first time that oleandrin, which is commonly used as a cardiac glycoside in this field, can very effectively induce DNA double-strand break damage and tumor cell apoptosis in tumor cells. Based on the above findings, the inventors have accomplished the present invention.

[0037] Before the present invention is described, it is to be understood that this invention is not limited to particular methods and experimental conditions described, since such methods and conditions may vary, and that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be used. picture being limiting, the scope of the invention will be limited only by the appended claims.

[0038] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this inve...

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Abstract

The invention discloses a novel homologous recombinant inhibitor. The invention provides an application of oleandrin or pharmaceutical salt thereof. Specifically, the oleandrin or the pharmaceutical salt thereof is used for preparing compositions or preparations for (i) inhibiting DNA repair and (ii) reducing drug tolerance of tumor cells. Based upon experiments, the oleandrin can obviously inhibit the DNA repair and / or reducing the drug tolerance of the tumor cells.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compounds, in particular, the invention relates to the application of oleandrin in inhibiting DNA repair and reducing the drug resistance of tumor cells. Background technique [0002] Chromosomal abnormalities and chromosomal instability often appear in tumor cells. At present, many tumor chemotherapy and targeted therapy drugs are aimed at inducing DNA damage and genome instability in tumor cells. For a long time, people have been exploring the therapeutic effect of traditional Chinese medicine extracts on tumors. [0003] DNA double-strand breaks are the most severe form of DNA damage. If not repaired effectively, it will lead to cell death. DNA double-strand breaks (DNA double-strand breaks, DSBs) repair mainly utilize homologous recombination and non-homologous end joining (Non-homologous end joining, NHEJ) mechanism. Homologous recombination plays a major role in it, and repairs the damaged ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P35/00
Inventor 应颂敏沈华浩鲍正强陈志华李雯
Owner 应颂敏
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