Western medicine mixture for treating spinal cord injury, and application thereof

Abstract

The invention discloses a western medicine mixture for treating spinal cord injury, and an application thereof. The western medicine mixture comprises monosialotetrahexosyl ganglioside sodium and sulbactam, wherein a mass ratio of the monosialotetrahexosyl ganglioside sodium to the sulbactam is (0.17-0.22):1, the mixture injection dose for an adult in the spinal cord injury treatment process is 0.95-1.00 mg / kg, and the administration time is 6-24 h after the spinal cord injury. Test treatment of the spinal cord injury model animals shows that the western medicine mixture can reduce cell apoptosis, promote the viability of neurons and inhibit formation of colloidal scars, and also can substantially improve the BBB score of treated animals, so the western medicine mixture has a substantial promotion effect on motor function recovery after the spinal cord injury. Compared with a common medicine methylprednisolone which is clinically used for treating the spinal cord injury at present, the western medicine mixture has the advantages of wide window, lasting treatment effect and good long-term effect.

Description

technical field [0001] The invention relates to the technical field of western medicine, in particular to a western medicine mixture for treating spinal cord injury and its application. Background technique [0002] With the development of the economic level of countries in the world, the incidence of spinal cord injury is increasing year by year. Spinal cord injury refers to the spinal cord injury caused by external direct or indirect factors, and various motor, sensory and sphincter dysfunctions, abnormal muscle tone and corresponding changes in pathological reflexes appear in the corresponding segments of the damage. Spinal cord injury is the most serious complication of spinal cord injury, often leading to severe dysfunction of the limbs below the level of injury. Spinal cord injury will not only bring serious physical and psychological harm to the patients themselves, but also cause a huge economic burden to the whole society. Due to the social and economic losses cau...

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Problems solved by technology

[0004] At present, drugs represented by methylprednisolone (methylprednisolone, referred to as methylprednisolone) have achieved certain curative effects in clinical application, but the adverse reactions of drugs and the timeliness of use make people continue to seek effective drugs. medicine

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