Pharmaceutical application of nafamostat

A technology of nalimus, which is applied in the direction of medical preparations containing active ingredients, drug combinations, pharmaceutical formulas, etc., can solve problems such as hindering the extension of regenerated axons and affecting functional recovery, so as to promote the recovery of motor function and promote survival , the effect of reducing apoptosis
CN103479612BActive Publication Date: 2015-06-17冯世庆
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
冯世庆
Publication Date
2015-06-17

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Abstract

The invention provides application of nafamostat in preparation of a medicament for treating spinal cord injury. The nafamostat is applied to therapeutic intervention of the spinal cord injury, and experiments show that the nafamostat can reduce apoptosis of cells, promote survival of neurons, inhibit formation of glial scars and remarkably improve the BBB score of a treated animal. Compared with a methylprednisolone medicament applied clinically at present, the nafamostat has the advantages of wider administration window, more lasting treatment effect and better long-term effect.
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Description

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to the use of namostat in preparing medicines for spinal cord injuries. Background technique

[0002] Nafamostat (nafamostat) is a synthetic serine proteolytic enzyme inhibitor with anticoagulant, antiplasmin and antiplatelet aggregation effects. Trypsin-like serine proteases such as plasmin, fibrinase, and CL-r and CL-s of the classical pathway of the complement system have a strong selective inhibitory effect. Nafamostat can inhibit the production of inflammatory mediators IL-6, IL-8, TNF-α, IL-1β and NOS, and is currently mainly used clinically for the treatment of acute pancreatitis. The inhibitory effect of nafamostat on the inflammatory response of organs other than the pancreas remains to be further studied.

[0003] The incidence of acute spinal cord injury (SCI) caused by various accidents has increased year by year in recent years, and has become a common clinical dis...

Claims

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