Western medicine combination for treating spinal cord injury and application of western medicine combination
A technology for spinal cord injury and western medicine, applied in the field of western medicine, to achieve the effects of inhibiting the formation of glial scars, wide administration window and lasting therapeutic effect
Inactive Publication Date: 2017-03-15
ZHENGZHOU ZHENGXIAN PHARMA CO LTD
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- Abstract
- Description
- Claims
- Application Information
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Problems solved by technology
[0005] Although a lot of research has been done on the pathophysiological mechanism of spinal cord injury in recent years, and the drugs represented by methylprednisolone (MP) have also achieved certain curative effects in clinical application, but the adverse reactions of the drugs and their Dosing limitations keep people searching for effective treatments
Method used
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Comparison scheme
Effect test
Embodiment 1
[0017] In an embodiment of the present invention, a western medicine combination for treating spinal cord injury is composed of methotrexate and nitrofurantoin; wherein, the mass ratio of methotrexate and nitrofurantoin is 0.09:1.
Embodiment 2
[0019] In an embodiment of the present invention, a western medicine combination for treating spinal cord injury is composed of methotrexate and nitrofurantoin; wherein, the mass ratio of methotrexate and nitrofurantoin is 0.10:1.
Embodiment 3
[0021] In an embodiment of the present invention, a western medicine combination for treating spinal cord injury is composed of methotrexate and nitrofurantoin; wherein, the mass ratio of methotrexate and nitrofurantoin is 0.11:1.
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The invention discloses a western medicine combination for treating spinal cord injury and application of the western medicine combination. The western medicine combination contains methotrexate and macrodantin, wherein the mass ratio of the methotrexate to the macrodantin is (0.09-0.13):1; when the western medicine combination is applied to treatment on spinal cord injury, the injection dosage of the western medicine combination to an adult is 1.9-2.1mg / kg, and the administration time is 6-12 hours after spinal cord injury. Trail treatment on model animals suffering from spinal cord injury shows that by using the western medicine combination, apoptosis can be reduced, nerve cell survival can be promoted, glial scar formation can be inhibited, BBB scoring of treated animals can be remarkably improved, and the western medicine combination disclosed by the invention has a remarkable promotion function on motor function recovery after spinal cord injury. Compared with a common medicine, namely, methylprednisolone for treating spinal cord injury, the western medicine combination disclosed by the invention is relatively wide in administration window, relatively long-lasting in treatment effect and relatively good in long-term effect.
Description
technical field [0001] The invention relates to the technical field of western medicine, in particular to a western medicine combination and application for treating spinal cord injury. Background technique [0002] Spinal cord injury is a serious complication of spinal fracture. Due to the displacement of the vertebral body or the protruding of bone fragments in the spinal canal, the spinal cord or cauda equina is damaged to varying degrees. It will be accompanied by fractures of the cervical, thoracic, thoracolumbar, lumbar, and sacral vertebrae, resulting in limb movement disorders, sensory disorders, and defecation disorders. It is more common in young adults, mostly males, and the most common injury site is the middle and lower cervical spinal cord, followed by the thoracolumbar junction. [0003] Spinal cord injury is composed of primary injury and secondary injury. The primary injury is tissue damage caused by mechanical external forces such as impact, cutting, bleed...
Claims
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IPC IPC(8): A61K31/519A61K31/4178A61P19/08A61P25/00
CPCA61K31/519A61K31/4178A61K2300/00
Inventor 不公告发明人
Owner ZHENGZHOU ZHENGXIAN PHARMA CO LTD
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