Applications of metabolic markers in diagnosing and identifying benign or malignant lesions of thyroid gland

A metabolic marker, thyroid technology, applied in the field of metabolomics, can solve the problems of high single marker or combined marker, diagnostic sensitivity and specificity that have not yet been found, and achieve high accuracy results
CN106526028AInactive Publication Date: 2017-03-22CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2017-03-22
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

The invention discloses applications of metabolic markers in diagnosing and identifying benign or malignant lesions of thyroid gland. The malignant lesions of thyroid gland are used for referring thyroid cancer, and the benign lesions of thyroid gland are used for referring thyroid benign node; and the metabolic markers are 1-oleoyl-sn-glycerol-3-phosphatidylcholine and / or 1-stearoyl-sn-glycerol-3-phosphatidylcholine. It is confirmed that when 1-oleoyl-sn- glycerol-3-phosphatidylcholine and 1-stearoyl-sn-glycerol-3-phosphatidylcholine are used for diagnosing and identifying thyroid cancer and thyroid benign node separately, certain accuracy is achieved; and when 1-oleoyl-sn- glycerol-3-phosphatidylcholine and 1-stearoyl-sn-glycerol-3-phosphatidylcholine are used for diagnosing and identifying thyroid cancer and thyroid benign node together, higher accuracy is achieved; so that 1-oleoyl-sn- glycerol-3-phosphatidylcholine and 1-stearoyl-sn-glycerol-3-phosphatidylcholine, and a composition of 1-oleoyl-sn- glycerol-3-phosphatidylcholine and 1-stearoyl-sn-glycerol-3-phosphatidylcholine can be taken as the metabolic markers in diagnosing and identifying thyroid cancer and thyroid benign node.
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Description

technical field

[0001] The invention relates to metabonomics, belongs to the field of measurement and testing, and specifically relates to the qualitative and quantitative analysis of small molecular metabolites in biological samples and the application as metabolic markers in the diagnosis and differentiation of benign and malignant thyroid lesions. Background technique

[0002] Thyroid cancer is one of the most common head and neck malignant endocrine tumors. Epidemiological surveys have found that in the past few decades, many cities around the world have seen an increase in the incidence of thyroid cancer. In Shanghai, the survey found that the incidence of thyroid cancer in men and women increased by 3.1% and 3.8% respectively; in Hong Kong, the incidence increased by 2.2% and 2.7%; The incidence rate of women increased by 6.1% [Document 1: Time trends and age-period-cohort analyzes on incidence rates of thyroid cancer in Shanghai and Hong Kong, BMC Cancer, 2014; Docum...

Claims

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