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Pharmaceutical composition for preventing and treating vitreous opacity

A technology of vitreous opacity and composition, which is applied in the direction of drug combination, active ingredients of heterocyclic compounds, medical raw materials derived from ferns/filamentous plants, etc., and can solve problems such as complicated etiology and pathogenesis, difficult to cure, and slow metabolism

Inactive Publication Date: 2017-04-26
JINAN HAOYU QINGTIAN PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The vitreous body itself has no blood vessels, and its metabolism is very slow. The vitreous body is mostly caused by lesions in the surrounding tissues. The pathological process is turbidity, liquefaction, fibrous tissue formation and contraction. The classification is called inflammatory turbidity caused by inflammation, and hemorrhagic turbidity caused by bleeding. Opacity, caused by degenerative changes, is called degenerative turbidity. Inflammatory vitreous opacity is mostly caused by iridocyclitis, choroiditis (uveitis), retinitis and other inflammatory cells, exudates and pathological products such as necrotic tissue It is caused by entering the vitreous body. The opacity caused by iridocyclitis is mainly anterior; the opacity caused by retinitis and choroiditis is mainly posterior. Its shape can be dusty, silky, fluffy, lumpy or Cord-shaped, grayish-white dot-like or white flocculent, snowball-like turbidity, hemorrhagic vitreous opacity refers to visual impairment complications caused by ocular trauma or retinal vascular disease, when the amount of bleeding is large, it is equivalent to sudden blindness in traditional Chinese medicine , the red light reflection of the fundus disappears, the fundus cannot be seen, and the vision is light perception. Under the ophthalmoscope, there are cord-like and fast-like opacities in the vitreous body. Degenerative vitreous opacities are more common in the elderly with high myopia, and there are also young people with the disease. The higher the degree of myopia, the earlier the age of onset, and there are also changes such as degeneration, turbidity and liquefaction caused by inflammation and bleeding. In short, vitreous opacity is not a single disease. The etiology and pathogenesis are complex, and it is difficult to cure with western medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1: Pharmaceutical composition for preventing and treating vitreous opacity and its preparation method

[0036] The composition and weight parts of the raw materials of the pharmaceutical composition for preventing and treating vitreous turbidity are: Pennisetum 5250g, vine sandalwood 425g, cymene flakes 245g, polygalic acid 55g, and 800g;

[0037] Preparation:

[0038] (1) According to the ratio of the raw materials, take Osmunda japonica, vine sandalwood, cymene flakes, polygalaic acid, and incense sticks, mix them, use 34.5% ethanol as a solvent, and extract at 32°C. The number of extractions is 6 times, each extraction time is 34 hours, each time the solvent consumption is 44 times of the total weight of the API, filtered to obtain drug residue A and extract A, extract A to recover ethanol, concentrate to a relative density of 1.08, filter , The drug solution passes through the LKS02 macroporous adsorption resin column, first eluted with water, and then eluted the ...

Embodiment 2

[0041] Example 2: Pharmaceutical composition for preventing and treating vitreous turbidity and its preparation method

[0042] The composition and weight parts of the raw materials of the pharmaceutical composition for preventing and treating vitreous turbidity are: Pennisetum lucidum 5200g, vine sandalwood 430g cymene tablets 230g, Polygallic acid 60g, and 700g;

[0043] Preparation:

[0044] (1) According to the ratio of the raw materials, take Osmunda japonica, vine sandalwood, cymene flakes, polygalaic acid, and incense sticks, mix them, use 34.5% ethanol as a solvent, and extract at 32°C. The number of extractions is 6 times, each extraction time is 34 hours, each time the solvent consumption is 44 times of the total weight of the API, filtered to obtain drug residue A and extract A, extract A to recover ethanol, concentrate to a relative density of 1.08, filter , The drug solution passes through the LKS02 macroporous adsorption resin column, first eluted with water, and then ...

Embodiment 3

[0047] Example 3: Pharmaceutical composition for preventing and treating vitreous opacity and its preparation method

[0048] The composition and weight parts of the raw materials of the pharmaceutical composition for preventing and treating vitreous turbidity are: Pennisetum lucidum 5300g, vine sandalwood 420g cymene tablets 260g, Polygalaic acid 50g, and 900g;

[0049] Preparation:

[0050] (1) According to the ratio of the raw materials, take Osmunda japonica, vine sandalwood, cymene flakes, polygalaic acid, and incense sticks, mix them, use 34.5% ethanol as a solvent, and extract at 32°C. The number of extractions is 6 times, each extraction time is 34 hours, each time the solvent consumption is 44 times of the total weight of the API, filtered to obtain drug residue A and extract A, extract A to recover ethanol, concentrate to a relative density of 1.08, filter , The drug solution passes through the LKS02 macroporous adsorption resin column, first eluted with water, and then el...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for preventing and treating vitreous opacity and a preparation method of the pharmaceutical composition. The pharmaceutical composition provided by the invention is prepared by proportioning the following medicinal raw materials: herb of dicranopteris linearis underw, root of dalbergia hancei benth, cymene slice, polygalic acid and common anotis herb, and the pharmaceutical composition can be prepared into various dosage forms in accordance with a conventional preparation process. The pharmaceutical composition is significant in curative effect on preventing and treating the vitreous opacity.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for preventing and treating vitreous opacity and a preparation method thereof. Background technique [0002] The vitreous body itself has no blood vessels, and its metabolism is very slow. The vitreous body is mostly caused by the lesions of the surrounding tissues. Its pathological process is turbid, liquefied, and fibrous tissue is formed and contracted. Its classification is called inflammatory turbidity caused by inflammation, and turbidity caused by bleeding is called hemorrhagic Opacity, which is caused by degenerative changes, is called degenerative opacity. Inflammatory vitreous opacity is mostly caused by iridocyclitis, choroiditis (uveitis), retinitis and other pathological products such as inflammatory cells, exudates and necrotic tissues It is caused by entering the vitreous body. The opacity caused by iridocycl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P27/02A61K31/56A61K31/37
CPCA61K36/12A61K31/37A61K31/56A61K36/48A61K36/74A61K2236/333A61K2236/39A61K2236/55
Inventor 不公告发明人
Owner JINAN HAOYU QINGTIAN PHARMA TECH CO LTD
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