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Application of poly(glycerol disebacate)

A technology of sebacic acid diglyceride and oil sebacate, which is applied in application, surgery, surgical adhesives, etc., can solve the problems of toxicity and easy damage, and achieve simple preparation method, good biocompatibility and The effect of biodegradability

Active Publication Date: 2017-05-10
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the monomers of commonly used chloroacrylic resin adhesives are toxic [Elasticity and safety of alkoxyethyl cyanoacrylate tissue adhesives [J]. ActaBiomaterialia, 2011, 7 (8): 3150-3157] and are restricted to be used in internal organs. Ethylene glycol swells with water and is easily destroyed【A versatile pH sensitive chondroitin sulfate-PEG tissue adhesive andhydrogel[J].Biomaterials,2010,31(10):2788-2797】

Method used

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  • Application of poly(glycerol disebacate)
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  • Application of poly(glycerol disebacate)

Examples

Experimental program
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Embodiment 1

[0029] (1) Synthesis of diglycidyl sebacate

[0030] Synthesis references of diglycidyl sebacate [Fine Control of Polyester Properties via Epoxide ROP Using Monomers Carrying Diverse Functional Groups[J].Macromolecular Bioscience,2012,12(6):822-829]. Use sodium wire to remove the water in the toluene, reflux to obtain anhydrous toluene for later use; use sodium hydroxide to remove the water in triethylamine, and obtain anhydrous triethylamine for later use after reflux.

[0031] A 500ml three-neck round-bottomed flask was subjected to anhydrous and anaerobic treatment, and 4ml of glycidol, 15ml of anhydrous triethylamine and 90ml of anhydrous toluene were added to the flask with a syringe, and then the flask was put into a mixed bath of ice and ethanol (-10 ℃). Then the sebacoyl chloride of 5ml was added dropwise in the flask, reacted for 7h, after the reaction ended, the resulting product was filtered with diatomaceous earth, after the filtrate was concentrated by rotary eva...

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Abstract

The invention relates to application of poly(glycerol disebacate). The poly(glycerol disebacate) is used as a hot melt adhesive for preparing a medical adhesive. The poly(glycerol disebacate) has good biocompatibility and biodegradability, has good crystallization property and good bonding property, and is hopeful to be used as the hot melt adhesive for preparing the medical adhesive.

Description

technical field [0001] The invention belongs to the field of medical adhesives, in particular to the application of poly(diglyceryl sebacate). Background technique [0002] The application of medical adhesives in surgical operations shortens the operation time, simplifies the operation process, and reduces the risk of postoperative infection or secondary operation. However, the existing adhesives still have some disadvantages, such as poor biocompatibility and not easy to degrade, thus limiting the application of medical adhesives in the human body. [0003] In surgery, there are two methods of wound closure: invasive closure and noninvasive closure. Invasive closure is mainly surgical suture, which is a common means of wound closure, but surgical suture requires high suture technology, the wound is prone to infection during the suturing process, and some postoperatively require a second operation, which increases the pain of the patient. Non-invasive closure is a newly em...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06A61L24/00C08G69/12
CPCA61L24/0042A61L24/06C08G69/12C08L67/00
Inventor 耿聪颖游正伟
Owner DONGHUA UNIV
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