Method for detecting propofol with elimination of sevoflurane interference

A detection method, the technology of propofol, applied in the direction of measuring device, preparation of test samples, material analysis through electromagnetic means, etc., can solve problems such as interference of propofol detection, shorten response time, realize on-line monitoring, Effect of eliminating interference from residual sevoflurane

Inactive Publication Date: 2017-06-20
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the residual inhalational anesthetic sevoflurane in the ventilator will interfere with the detect

Method used

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  • Method for detecting propofol with elimination of sevoflurane interference
  • Method for detecting propofol with elimination of sevoflurane interference
  • Method for detecting propofol with elimination of sevoflurane interference

Examples

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Embodiment 1

[0037] Adopt the present invention to measure propofol and sevoflurane simultaneously, its ion mobility spectrogram is as follows figure 2 shown.

Embodiment 2

[0039] Simultaneous detection of propofol and sevoflurane using time-resolved dynamic dilution ion mobility spectrometry, the concentration of propofol and sevoflurane as a function of time image 3 , and its dynamic ion mobility spectrum is shown in Figure 4 , the repeatability of its detection is as follows Figure 5 .

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Abstract

The invention discloses a method for detecting propofol with elimination of sevoflurane interference. Based on an ion mobility spectrometry technique and a time-resolved dynamic dilution sample introduction technique, the method realizes dynamic dilution of propofol and sevoflurane, thereby eliminating the interference of residual sevoflurane in anesthetics, and realizing continuous on-line monitoring of propofol in intra-operative expiratory air.

Description

technical field [0001] Based on ion mobility spectrometry and time-resolved dynamic dilution sampling technology, the present invention designs a time-resolved dynamic dilution ion mobility spectrometry detection method, eliminates the interference of residual sevoflurane in anesthesia machines, and realizes the detection of propofol during surgery Continuous online monitoring. Background technique [0002] Propofol is a commonly used intravenous anesthetic, which has been widely used in induction of anesthesia, maintenance of anesthesia and sedation of critically ill patients in ICU. During the operation, the concentration of propofol in the exhaled breath of surgical patients is closely related to the concentration of propofol in the blood. Therefore, online monitoring of the concentration of propofol in the exhaled breath is expected to become a non-invasive method for predicting the blood concentration of propofol. method. [0003] At present, the methods used to deter...

Claims

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Application Information

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IPC IPC(8): G01N27/62G01N1/34
CPCG01N27/622G01N1/34
Inventor 李海洋蒋丹丹王祯鑫彭丽英刘骥巍
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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