Adapter mediated adenovirus targeting drug-delivery system and structuring method thereof
A technology of targeted drug delivery and construction method, which is applied in the field of aptamer-mediated adenovirus targeted drug delivery system and its construction, can solve problems such as limiting the application of aptamer, and achieves improved serum stability, enhanced targeting, The effect of prolonging the cycle time
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[0041] In order to make the purpose, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.
[0042] The application principle of the present invention will be described in detail below in conjunction with the accompanying drawings.
[0043] The aptamer-mediated adenovirus targeted drug delivery system provided in the examples of the present invention uses PEG as a linker to develop a new EpDT3-modified Ad5-PTEN gene drug delivery system EpDT3-PEG-Ad5-PTEN (EPAP).
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