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Compound with anti-cancer activity and preparation method and application thereof

An anti-cancer activity and compound technology, which is applied in the preparation of sugar derivatives, chemical instruments and methods, separation/purification of carboxylic acid compounds, etc., to achieve the effect of inhibiting the proliferation of liver cancer cells and having good anti-cancer activity

Active Publication Date: 2017-07-25
HUNAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on discovering compounds with anticancer activity from Cyclocarya paliurus

Method used

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  • Compound with anti-cancer activity and preparation method and application thereof
  • Compound with anti-cancer activity and preparation method and application thereof
  • Compound with anti-cancer activity and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] This example provides a compound 1 with anticancer activity, its structure is as follows:

[0042]

[0043] The characterization information of the compound 1 is as follows Figure 1~6 shown.

Embodiment 2

[0045]This example provides a compound 2 with anticancer activity, its structure is as follows:

[0046]

[0047] The characterization information of the compound 2 is as follows: Figure 7-12 shown.

Embodiment 3

[0049] This example provides a compound 3 with anticancer activity, its structure is as follows:

[0050]

[0051] The characterization information of the compound 3 is as follows Figures 13 to 18 shown.

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Abstract

The invention relates to a compound with the anti-cancer activity. The compound has a structure as shown in a general formula I. The compound can be extracted from cyclocarya paliurus by adopting a method which is simple, convenient and easy to operate. The compound provided by the invention can effectively inhibit proliferation of human breast cancer cells and hepatoma carcinoma cells; an effect of the compound is superior to that of a classical anti-cancer compound cis-platinum; the compound is excellent in anti-cancer activity, can be used for preparing medicines and health products, and has potential application value. The general formula I is shown in the description.

Description

technical field [0001] The invention relates to the field of natural product chemistry, in particular to a compound with anticancer activity and its preparation method and application. Background technique [0002] Cyclocarya paliurus (Latin name: Cyclocarya paliurus.), aliases: money tree, hemp willow, green money plum, mountain hemp willow, mountain tree. Juglandaceae and Cyclocarya genus plants are found in many provinces in southern my country, mostly in sporadic distribution. Cyclocarya paliurus is a rare tree species that survived the Quaternary Glaciation, and it only exists in China. Cyclocarya paliurus is known as the giant panda in the plant world and the third tree in the medical world. People know that willow, the first tree in the medical field, produced aspirin, which has anti-inflammatory, anti-thrombotic and anti-thrombotic properties, which opened up the first revolution in the history of human health. After cardiovascular and cerebrovascular diseases, ca...

Claims

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Application Information

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IPC IPC(8): C07C69/732C07C69/734C07C67/48C07C59/46C07C51/42C07H15/24C07H1/08A61P35/00
Inventor 王炜刘斌陈艳娇江星明箭雨青李斌彭彩云黄建华谢雪姣
Owner HUNAN UNIV OF CHINESE MEDICINE
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