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Medicinal composition with anti-depression effect and preparation method of medicinal composition

A composition and anti-depressant technology, which can be used in drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve the problems of high toxic and side effects and high cost of antidepressant drugs

Active Publication Date: 2017-10-20
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Modern chemical antidepressants are expensive, and have high toxicity and side effects. Therefore, it is necessary to find antidepressants with low toxicity and high efficacy from traditional Chinese medicine and natural medicines, especially compound antidepressants.

Method used

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  • Medicinal composition with anti-depression effect and preparation method of medicinal composition
  • Medicinal composition with anti-depression effect and preparation method of medicinal composition
  • Medicinal composition with anti-depression effect and preparation method of medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0253] Prescription: evening primrose 300g, pulsatilla 300g, nasturtium 300g;

[0254] Preparation method: (1) After mixing 300g of dried evening primrose and 300g of nasturtium, pulverize into coarse powder, CO 2 Supercritical extraction, CO 2 The supercritical extraction conditions are: extraction pressure 30MPa, extraction temperature 35°C, CO 2 Flow 30L·h -1 , extraction time 1.5h; get evening primrose and nasturtium extract, use β-cyclodextrin inclusion compound to get β-cyclodextrin inclusion complex; evening primrose and nasturtium CO 2 The medicinal residues after supercritical extraction are kept for future use;

[0255] (2) take the evening primrose and nasturtium CO obtained in step (1) 2 The medicinal residues after supercritical extraction were reflux extracted twice with 8 times the amount of 65% ethanol, each time for 1 hour, the extracts were combined, filtered, and the filtrate was concentrated to obtain the extract I, which was set aside;

[0256] (3) Ta...

Embodiment 2

[0273] Prescription: evening primrose 300g, pulsatilla 300g, nasturtium 300g;

[0274] Preparation method: (1) After mixing 300g of dried evening primrose and 300g of nasturtium, pulverize into coarse powder, CO 2 Supercritical extraction, CO 2 The supercritical extraction conditions are: extraction pressure 30MPa, extraction temperature 35°C, CO 2 Flow 30L·h -1 , extraction time 1.5h; get evening primrose and nasturtium extract, use β-cyclodextrin inclusion compound to get β-cyclodextrin inclusion complex; evening primrose and nasturtium CO 2 The medicinal residues after supercritical extraction are kept for future use;

[0275] (2) take the evening primrose and nasturtium CO obtained in step (1) 2 The medicinal residues after supercritical extraction were reflux extracted twice with 8 times the amount of 65% ethanol, each time for 1 hour, the extracts were combined, filtered, and the filtrate was concentrated to obtain the extract I, which was set aside;

[0276] (3) Ta...

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Abstract

The invention discloses a medicinal composition with an anti-depression effect and a preparation method of the medicinal composition. The medicinal composition is prepared from the following ingredients in parts by weight: 1-3 parts of radix oenotherae erythrosepalae, 1-3 parts of radix pulsatillae, and 1-3 parts of flos trollii. The medicinal composition disclosed by the invention has the anti-depression effect, is good in treatment effect, takes effect rapidly, is lasting in effect, and is free of toxic and side effects; the preparation process is simple, radix pulsatillae, radix oenotherae erythrosepalae and flos trollii are common traditional Chinese medicines, the dosage is low, and the preparation cost is low.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and more specifically relates to a pharmaceutical composition with antidepressant effect and a preparation method thereof. Background technique [0002] Depression belongs to the category of affective mental disorders. It is a syndrome characterized by significant and persistent depression. With the intensification of various stress factors, depression has become a common disease in modern society with a high incidence rate, and its incidence rate is rising rapidly, seriously affecting the quality of life of patients and their families, and even endangering the lives of patients. Currently, conventional antidepressants include the following classes: [0003] 1. Monoamine oxidase inhibitors (MAOIs) and reversible selective monoamine oxidase inhibitors (RIMA): The monoamine oxidase inhibitor iproniazid is the first drug used to treat depression. The main mechanism is to inhibi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P25/24A61P25/18
CPCA61K36/185A61K36/71A61K2236/331A61K2236/333A61K2236/37A61K2236/39A61K2236/51A61K2236/55A61K2300/00
Inventor 吴迪祁永华安丽凤王业秋郝美玲郑坤李博谦李晓亮李硕熙吕丹
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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