Preparation method of soluble paper-shaped alginate compound bleeding-stopping membrane

A hemostatic film and soluble technology, applied in the field of medical and health materials, can solve the problems of complex production process and low production efficiency, etc.

Inactive Publication Date: 2017-10-24
INST OF APPLIED CHEM JIANGXI ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to disclose a preparation method of a soluble paper-like alginate composite hemostatic film in order to solve the defects of complex production process and low production efficiency of currently marketed soluble hemostatic materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Weigh 6 grams of sodium alginate and 4 grams of PVA, add 100ml of deionized water, and magnetically stir in a water bath at 80°C for 2 hours to dissolve to form a transparent solution, then add 0.01 grams of calcium chloride, continue stirring for 2 hours, and cool to room temperature to obtain a transparent spinning solution , put the spinning liquid into the liquid storage device, and use the electrospinning device to form a soluble paper-like alginate composite hemostatic membrane in one step. Spinning conditions: voltage 30KV, solution flow rate 3ml / h, distance 10cm. Hemostatic film thickness 0.2mm, in vitro cytotoxicity level 1, weight per unit area 30g / m 2 .

Embodiment 2

[0017] Weigh 5 grams of sodium alginate and 5 grams of PVA, add 100ml of deionized water, stir magnetically in a water bath at 80°C for 2 hours to dissolve and form a transparent solution, then add 0.01 grams of calcium chloride, continue stirring for 2 hours, and cool to room temperature to obtain a transparent spinning solution , put the spinning liquid into the liquid storage device, and use the electrospinning device to form a soluble paper-like alginate composite hemostatic membrane in one step. Spinning conditions: voltage 30KV, solution flow rate 3ml / h, distance 10cm. The thickness of the hemostatic film is 0.3mm, and the weight per unit area is 50g / m 2 .

Embodiment 3

[0019] Weigh 6 grams of sodium alginate and 4 grams of PVA, add 100ml of deionized water, and magnetically stir in a water bath at 80°C for 2 hours to dissolve to form a transparent solution, then add 0.01 grams of calcium acetate, continue stirring for 2 hours, and cool to room temperature to obtain a transparent spinning solution. The spinning liquid was put into the liquid storage device, and the soluble paper-like alginate composite hemostatic membrane was prepared in one step by using the electrospinning device. Spinning conditions: voltage 30KV, solution flow rate 3ml / h, distance 10cm. Hemostatic film thickness 0.5mm, in vitro cytotoxicity level 1, weight per unit area 40g / m 2 .

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Abstract

The invention relates to a preparation method of a soluble paper-shaped alginate compound bleeding-stopping membrane. The bleeding-stopping membrane contains the following materials in percentage by mass: 40%-79.9% of alginate, 20%-60% of polyvinyl alcohol and 0-0.1% of a calcium salt crosslinking agent. The preparation method comprises the following steps: (1) dissolving alginate and polyvinyl alcohol into water in proportion, so as to form a uniform and transparent solution with a concentration of 7%-15%, adding the calcium salt crosslinking agent, carrying out crosslinking, so as to obtain a spinning solution; and (2) putting the spinning solution into a constant-temperature liquid storage device, carrying out processing and once formation by virtue of electrostatic spinning equipment, so as to obtain the soluble paper-shaped alginate compound bleeding-stopping membrane. The soluble paper-shaped alginate compound bleeding-stopping membrane has a porous net-shaped structure and a relatively high surface area and can mutually act with blood of a wound to form gel, so that the hemostasis process is accelerated; and meanwhile, calcium ions in the bleeding-stopping membrane material are released to the surface of the wound so as to start blood coagulation factors, so that the two bleeding-stopping effects of gel hemostasis and calcium ion blood coagulation are achieved.

Description

technical field [0001] The invention relates to a preparation method of a soluble paper-like alginate composite hemostatic membrane, which belongs to the technical field of medical and sanitary materials. Background technique [0002] Injuries are unavoidable in daily life, and bleeding is the main complication after trauma, so local hemostatic materials are very important. Existing hemostatic gauze, hemostatic fibers and hemostatic bandages and other hemostatic materials have certain limitations in use, such as easy adhesion to the wound, difficult dressing change, easy infection and suppuration of the wound, causing pain to the patient. In order to reduce unnecessary deaths caused by blood loss, the medical field has put forward higher requirements on the performance of hemostatic materials, and it is imperative to develop hemostatic materials with better hemostatic effect, convenient use and less pain for patients. Based on the performance requirements of hemostatic mate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/06A61L24/00
CPCA61L24/0015A61L24/0036A61L24/06A61L24/08A61L2300/102A61L2300/418A61L2400/04C08L5/04C08L29/04
Inventor 孙复钱舒泉水张鹏
Owner INST OF APPLIED CHEM JIANGXI ACAD OF SCI
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