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The application of the active part of the cornflower inflorescence as a drug for the preparation of 5α reductase inhibitors

A reductase inhibitor and active site technology, which is applied to the active site of cornflower inflorescence as an application field for preparing a 5α reductase inhibitor drug, can solve the problem of large side effects, not very prominent effects, and unstable plant crude extracts. problem, to achieve a good inhibitory effect, a significant effect

Active Publication Date: 2021-02-09
新疆金海娜生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention provides an active part of cornflower inflorescence as an application for preparing 5α-reductase inhibitor medicine, which overcomes the deficiencies of the prior art and can effectively solve the current problem of inhibiting 5α-reductase activity of cornflower extracts. The research is rarely seen in the literature, and the curative effect of the crude plant extract is not stable enough during use, the effect is not very prominent, and the problem of side effects of the western drug finasteride as a drug that inhibits the activity of 5α reductase

Method used

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  • The application of the active part of the cornflower inflorescence as a drug for the preparation of 5α reductase inhibitors
  • The application of the active part of the cornflower inflorescence as a drug for the preparation of 5α reductase inhibitors
  • The application of the active part of the cornflower inflorescence as a drug for the preparation of 5α reductase inhibitors

Examples

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Effect test

Embodiment 1

[0029] Example 1, the application of the active part of the cornflower inflorescence as a drug for the preparation of 5α-reductase inhibitors. In the present invention, the inhibitory effect of the active part of the cornflower inflorescence on the activity of 5a reductase is greatly improved compared with the current western medicine finasteride, and the active part of the cornflower inflorescence can be obtained from the prior art obtained from.

Embodiment 2

[0030] Embodiment 2, as the optimization of Example 1, the active part of the cornflower inflorescence is obtained by the following method: the flowers of the cornflower are picked, and the flowers of the cornflower are dried to a water content lower than 20%, and the dried cornflower is After the cornflower is crushed, carry out alcohol extraction for 1 to 3 times, and use 5 times to 15 times of ethanol solution with a concentration of 50% to 100% for each alcohol extraction, and combine the extracts to obtain the cornflower extract;

[0031] The second step is to concentrate the extract to 1 / 6 to 1 / 3 of the initial volume of the extract to obtain concentrated solution I;

[0032] The third step is to use the macroporous resin column to carry out the first step of refining the concentrated solution I, and first use 2 to 5 times of the volume of the macroporous resin column to elute with pure water, discard the eluent, and then use 3 to 4 Elute with 60% to 95% ethanol solution...

Embodiment 3

[0037]Example 3, as an optimization of Example 2, in the second step, the method of concentrating the extract to obtain the concentrated solution I is: use normal temperature heating and concentration, the concentration temperature is 60°C to 95°C; or, use reduced pressure concentration, concentrate The temperature is 45°C to 80°C, and the vacuum degree is not greater than 50mbar; or, the concentration temperature can be set at 50°C to 65°C, and the vacuum degree is 26mbar to 150mbar by evaporative concentration.

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Abstract

The invention relates to the technical field of 5-alpha reductase inhibitors, and provides applications of a cornflower inflorescence active part in serving as a medicine for preparing the 5-alpha reductase inhibitor. According to the technical scheme, the cornflower inflorescence active part is further refined through a modern separation technology and an activity research method, the cornflower inflorescence active part has a relatively good inhibition effect for the activity of the 5-alpha reductase, and meanwhile, the cornflower inflorescence active part adopted in the invention is a pure green plant extract, thus being safe and non-toxic and being remarkable in effect in inhibiting the activity of the 5-alpha reductase.

Description

technical field [0001] The invention relates to the technical field of 5α-reductase inhibitors, and relates to the application of the active part of cornflower inflorescences as a drug for preparing 5α-reductase inhibitors. Background technique [0002] Cornflower (Centaurea cyanus L.) is a plant of the genus Centaurea (Centaurea L.), and it is used in parks, gardens and campuses in Xinjiang, Qinghai, Gansu, Shaanxi, Hebei, Shandong, Jiangsu, Hubei, Hubei, Guangdong and Tibet, etc. Commonly cultivated for viewing. It has been planted on a large scale in Yili, Xinjiang. It is a traditional botanical medicine in Europe, often used to treat eye inflammation, the main active ingredient is its polysaccharide part; cornflower extract is used as a hair care ingredient in the cosmetics industry. [0003] There are type I and type II isoenzymes of α-reductase. Studies have found that non-male target tissues and ovaries of mice mainly contain type I enzymes and their mRNA, especiall...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61P17/14A61K133/00
CPCA61K36/28A61K2236/333A61K2236/51A61K2236/55
Inventor 张显文
Owner 新疆金海娜生物科技有限公司
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