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A kind of amniotic membrane stem cell gel and its preparation method and application

A stem cell and gel technology, applied in the field of amniotic membrane stem cell gel and its preparation, can solve the problems of long-term maintenance, easy loss of activity, poor effect, etc., and achieves good tissue repair function, high activity, good repair function and The effect of moisturizing function

Active Publication Date: 2020-12-04
JIANGXI RUIJI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] When amniotic membrane stem cells are directly applied to wounds, their activity is easily lost and cannot be maintained for a long time, resulting in poor results

Method used

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  • A kind of amniotic membrane stem cell gel and its preparation method and application
  • A kind of amniotic membrane stem cell gel and its preparation method and application
  • A kind of amniotic membrane stem cell gel and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] An amniotic membrane stem cell gel, in parts by weight, consists of the following components: 60 parts of amniotic membrane stem cells, 50 parts of platelet-rich plasma, 75 parts of glycerin, 60 parts of chitosan, 12 parts of palmitic acid, 7 parts of phenoxyethanol, 17 parts of triethanolamine, 5 parts of glutathione, 7 parts of dextran, 600 parts of deionized water, 10 parts of sodium polyacrylate, 15 parts of sodium hyaluronate, 5 parts of α-bisabolol, 10 parts of hydroxyethyl cellulose 8 parts, 8 parts of isononyl isononanoate, 3 parts of isopropyl myristate, 5 parts of N-methylolacrylamide, 28 parts of polyacrylate pressure-sensitive adhesive, 6 parts of cyclomethicone, Acrylates / C10-30 alkanol acrylate crosspolymer 12 parts, hydroxyethyl acrylate-acryloyl dimethyl sodium taurate copolymer 5 parts.

[0027] The platelet-rich plasma comes from concentrated platelets collected directly by a blood cell separator (machine-collected platelets), blood collected from a ve...

Embodiment 2

[0061] An amniotic membrane stem cell gel, in parts by weight, consists of the following components: 52 parts of amniotic membrane stem cells, 45 parts of platelet-rich plasma, 72 parts of glycerin, 58 parts of chitosan, 9 parts of palmitic acid, 6 parts of phenoxyethanol, 15 parts of triethanolamine, 7 parts of glutathione, 9 parts of dextran, 630 parts of deionized water, 8 parts of sodium polyacrylate, 13 parts of sodium hyaluronate, 4 parts of α-bisabolol, 8 parts of hydroxyethyl cellulose 9 parts, 9 parts of isononyl isononanoate, 5 parts of isopropyl myristate, 7 parts of N-methylolacrylamide, 24 parts of polyacrylate pressure-sensitive adhesive, 8 parts of cyclomethicone, Acrylates / C10-30 alkanol acrylate crosspolymer 11 parts.

[0062] The platelet-rich plasma comes from concentrated platelets collected directly by a blood cell separator (machine-collected platelets), blood collected from a vein (anticoagulated blood) and platelet concentrate prepared by centrifugation...

Embodiment 3

[0074] An amniotic membrane stem cell gel, in parts by weight, consists of the following components: 54 parts of amniotic membrane stem cells, 42 parts of platelet-rich plasma, 65 parts of glycerin, 55 parts of chitosan, 8 parts of palmitic acid, 5 parts of phenoxyethanol, 13 parts of triethanolamine, 6 parts of glutathione, 8 parts of dextran, 650 parts of deionized water, 7 parts of sodium polyacrylate, 12 parts of sodium hyaluronate, 3 parts of α-bisabolol, 5 parts of hydroxyethyl cellulose 9 parts, 9 parts of isononyl isononanoate, 4 parts of isopropyl myristate, 6 parts of N-methylolacrylamide, 26 parts of polyacrylate pressure-sensitive adhesive, 9 parts of cyclomethicone, Acrylates / C10-30 alkanol acrylate crosspolymer 10 parts, hydroxyethyl acrylate-sodium acryloyldimethyl taurate copolymer 3 parts.

[0075] The platelet-rich plasma comes from concentrated platelets collected directly by a blood cell separator (machine-collected platelets), blood collected from a vein (...

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Abstract

The invention provides an amniotic membrane stem cell gel, which consists of the following components in parts by weight: amniotic membrane stem cells, platelet-rich plasma, glycerin, chitosan, palmitic acid, phenoxyethanol, triethanolamine, glutathione, and dextran , deionized water, sodium polyacrylate, sodium hyaluronate, α-bisabolol, isononyl isononanoate, isopropyl myristate, N-methylolacrylamide, polyacrylate pressure-sensitive adhesive, Cyclomethicone, Acrylates / C10‑30 Alkyl Acrylate Crosspolymer, and Hydroxyethyl Acrylate‑Sodium Acryloyldimethyltaurate Copolymer. The gel of the present invention has good repairing function and moisturizing function, and can realize the sustained release of active substances of platelet-rich plasma and amniotic membrane stem cells. Good tissue repair function has a good effect on difficult-to-heal wounds and cartilage damage.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to an amniotic membrane stem cell gel and a preparation method and application thereof. Background technique [0002] Autologous platelet-rich plasma (Platelet-rich plasma, PRP) is the platelet concentrate produced by autologous blood. A large number of clinical studies have reported that PRP contains a large number of various platelet-derived cell growth factors, which can promote the repair of various tissues, and can promote the repair of bone and soft tissue. The promotion of bone defect repair by PRP may be mainly based on the following two mechanisms: one is that PRP is activated into platelet-rich gel (Platelet-rich gel, PRG) under the action of an activator, which contains a large amount of fibrinogen, which can seal the wound and promote tissue regeneration. contraction and healing; the other is platelet contraction during the polymerization process, degranulation rel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/52A61L27/36A61L27/38A61L27/20A61L27/16A61K35/50A61K9/06A61K47/38A61P19/02A61P17/02A61P19/08A61P9/10A61K35/16
CPCA61K9/0002A61K9/06A61K35/16A61K35/50A61K47/38A61L27/16A61L27/20A61L27/3616A61L27/3834A61L27/52A61L2300/412A61L2300/604A61L2430/00A61L2430/06A61L2430/34C08L1/286C08L5/08C08L33/08C08L33/14
Inventor 刘德伍傅筱冲吕虎苗春云周星辛红滕志强
Owner JIANGXI RUIJI BIOTECH CO LTD
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