Method and device for detecting mutated proteins

A mutant protein and detection method technology, which is applied in the field of mutant protein detection methods and devices, and can solve problems such as inability to detect mutant proteins

Inactive Publication Date: 2017-11-28
天津市湖滨盘古基因科学发展有限公司
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Problems solved by technology

[0003] In the prior art, protein mutation analysis is generally performed by establishing a series of electrophoresis and analyzing the DNA conformation in the sample, while the prior art only analyzes whether a certain protein has a mutation, and cannot detect the mutation of the sample. What are the mutated proteins in

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  • Method and device for detecting mutated proteins
  • Method and device for detecting mutated proteins
  • Method and device for detecting mutated proteins

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Embodiment Construction

[0045] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments It is a part of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work belong to the protection of the present invention. scope.

[0046] Such as figure 1 As shown, the embodiment of the present invention provides a method for detecting a mutant protein, which may include the following steps:

[0047] Step 101: Obtain the transcriptome data corresponding to the sample;

[0048] Step 102: comparing the transcriptome data with the mitochondrial database, and outputting the non-mito...

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Abstract

The invention provides a method and a device for detecting mutated proteins. The method includes acquiring transcriptome data corresponding to samples; comparing the transcriptome data to mitochondrion databases and outputting non-mitochondrion sequences according to comparison results of the transcriptome data and the mitochondrion databases; transforming nucleotide sequences in the non-mitochondrion sequences into amino acid sequences, comparing the transformed amino acid sequences to protein databases and extracting amino acid sequences with homogenous rates in first set ranges and amino acid lengths in second set ranges from comparison results of the transformed amino acid sequences and the protein databases; comparing the extracted amino acid sequences with the homogenous rates in the first set ranges and the amino acid lengths in the second set ranges to NCBI (national center of biotechnology information) and determining the mutated proteins according to comparison results of the extracted amino acid sequences and the NCBI. According to the scheme, the method and the device have the advantage that the mutated proteins in the samples can be detected by the aid of the method and the device.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a method and device for detecting a mutant protein. Background technique [0002] Cancer refers to malignant tumors originating from epithelial tissue. Common malignant tumors include liver cancer and lung cancer. Worldwide, the number of deaths caused by malignant tumors accounts for one-eighth of the total number of deaths, more than the total number of deaths from AIDS, tuberculosis and malaria, and the incidence of malignant tumors is increasing year by year. The occurrence of malignant tumors is the result of the joint action of the environment and genes, and gene mutations can lead to protein mutations. Therefore, the study of mutant proteins is still a research hotspot. [0003] In the prior art, the analysis of protein mutation is generally carried out by establishing a series of electrophoresis and analyzing the DNA conformation in the sample, while the prior art only analy...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/18G06F19/28
CPCG16B20/00G16B50/00
Inventor 张耀洲冯建华吴玉乾张树军李冬梅焦春彬陈玉皎胖铁良王文雅
Owner 天津市湖滨盘古基因科学发展有限公司
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