A platinum complex for inhibiting skov3 cells and its synthesis method

A technology of platinum complexes and synthesis methods, applied in the field of medicine, can solve problems such as unfavorable metal complexes, lack of hyperconjugated planar large π bond systems, etc., achieve high-efficiency anti-tumor activity, good medicinal value, and easy control of reaction conditions Effect

Active Publication Date: 2019-09-06
YULIN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effective component of Evodia rutaecarpa Evodiae has well-coordinated nitrogen and oxygen atoms in its structure, but it lacks a hyperconjugated planar large π bond system, which is not conducive to chelating with metal ions to form metal complexes from the structure. Although some derivatives of Evodia rutacarpa have been developed as anti-tumor drugs, the research on complexes of evodiamine and platinum has not been reported, and there are almost no reports on other metal complexes of evodiamine.

Method used

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  • A platinum complex for inhibiting skov3 cells and its synthesis method
  • A platinum complex for inhibiting skov3 cells and its synthesis method
  • A platinum complex for inhibiting skov3 cells and its synthesis method

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Weigh evodiamine (0.029g, 0.1mmol), Pt(DMSO) 2 Cl 2 (0.060g, 0.15mmol), were dissolved in 5ml of chloroform and 5ml of methanol respectively, placed in a 50ml round bottom flask after mixing, and reacted for 3 hours under the condition of heating in a water bath at 55°C to make it react completely. Filtrate, volatilize at room temperature to obtain dark brown massive crystals, wash with petroleum ether and chloroform, and dry to obtain evodiamine platinum complex with a yield of 81.1%.

[0025] Product testing: Infrared spectrum and X-ray single crystal diffraction analysis were carried out on the dark brown solid product obtained above, as shown in Figures 1-2; figure 1 It is the infrared spectrogram of the platinum complex of the present invention; figure 2 It is the X-ray single crystal diffraction structure diagram of the platinum complex described in the present invention.

[0026] figure 1 Specific spectral features are as follows:

[0027] IR spectrum: 3317...

Embodiment 2

[0052] Weigh evodiamine (2.9g, 10mmol), Pt(DMSO) 2 Cl 2 (6.0g, 15mmol), respectively dissolved in 250ml of chloroform and 250ml of methanol, mixed and placed in a 1000ml round-bottomed flask, reacted for 3 hours under the condition of heating in a water bath at 55°C to make it react completely. Filtrate, volatilize at room temperature to obtain dark brown massive crystals, wash with petroleum ether and chloroform, and dry to obtain evodiamine platinum complex with a yield of 79.4%.

[0053] The product detection method is the same as in Example 1.

Embodiment 3

[0055] Weigh evodiamine (2.9g, 10mmol), Pt(DMSO) 2 Cl 2 (6.0g, 15mmol), respectively dissolved in 250ml of chloroform and 250ml of methanol, mixed and placed in a 1000ml round bottom flask, reacted under the condition of heating in a water bath at 65°C for 6 hours to make it completely reacted. Filtrate, volatilize at room temperature to obtain dark brown massive crystals, wash with petroleum ether and chloroform, and dry to obtain evodiamine platinum complex with a yield of 81.4%.

[0056] The product detection method is the same as in Example 1.

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Abstract

The invention discloses a platinum complex for inhibiting SKOV3 cells and a synthesis method thereof, belonging to the technical field of medicine. The aim is to provide a ligand based on evodiamine and DMSO as an auxiliary ligand to synthesize a platinum complex for inhibiting SKOV3 cells. The invention also provides a synthesis method of the platinum complex. The structural formula of the platinum complex is: The invention can be used to prepare antitumor drugs.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a platinum complex for inhibiting SKOV3 cells and a synthesis method thereof. Background technique [0002] The present invention selects Rutaecarpine (Rutaecarpine), an active ingredient derived from the alkaloids of the traditional Chinese medicine Evodia rutaecarpine, as a platinum complex synthesized as a ligand. Since the successful clinical use of cisplatin anti-tumor metal drugs, the research on platinum complexes has attracted more and more attention. However, due to the toxic side effects and drug resistance of platinum complexes, it has been found Platinum complexes with antitumor activity have always been a research hotspot in this field. The effective component of Evodia rutaecarpa Evodiae has well-coordinated nitrogen and oxygen atoms in its structure, but it lacks a hyperconjugated planar large π bond system, which is not conducive to chelating with metal ions to ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F15/00A61P35/00
Inventor 谭明雄申文英覃其品
Owner YULIN NORMAL UNIVERSITY
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