Method for building mouse acute radiation duodenitis model

A technique of duodenum, establishing method, applied in the field of radiology

Active Publication Date: 2018-01-05
CHINA INST FOR RADIATION PROTECTION
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  • Abstract
  • Description
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Problems solved by technology

At present, there is still no effective clinical treatment for radiation-induc

Method used

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  • Method for building mouse acute radiation duodenitis model
  • Method for building mouse acute radiation duodenitis model
  • Method for building mouse acute radiation duodenitis model

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Embodiment Construction

[0023] The present invention will be described in detail below in conjunction with the accompanying drawings and embodiments.

[0024] The invention provides a specific method and identification for establishing a mouse acute radiation enteritis model.

[0025] The SPF grade Kunming mouse of the present invention was purchased from China National Institutes for Food and Drug Control, aged 6-8 weeks, with a body weight of 26-28 g. There were 10 rats in the control group and 14 rats in the 8Gy dose group, half male and half male.

[0026] The cobalt-60 teletherapy machine described in the present invention is provided by the radiotherapy department of the affiliated hospital of the China Institute of Radiation Protection.

[0027] The ELISA kit described in the present invention was purchased from American R&D Company.

[0028] Such as figure 1 As shown, the establishment method of mouse acute radiation duodenitis model provided by the invention comprises the steps:

[0029]...

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Abstract

The invention belongs to the technical field of radiation medicine, and specifically relates to a method for building a mouse acute radiation duodenitis model. According to the method, 8Gy gamma-ray irradiation is performed on mice, the irradiation part is the abdomen, duodenitis pathological analysis is performed on the mice after two weeks since the irradiation is conducted, and the protein expression levels of an apoptosis related factor BCL-2 and an inflammation related factor TGF-beta1 are detected. According to the invention, an irradiation method which is closer to clinical radiotherapyis adopted to build the radiation duodenitis model, thereby providing an experimental basis for prevention and treatment research for clinical radiation intestinal injuries.

Description

technical field [0001] The invention belongs to the technical field of radiation medicine, and in particular relates to a method for establishing a mouse model of acute radiation-induced duodenitis. Background technique [0002] The animal model of human disease is an animal experiment object with the simulated performance of human disease. The use of animal model is a very important experimental method in modern biomedical scientific research, which helps to understand the occurrence and development of human disease more conveniently and effectively. Law, so as to provide an experimental basis for the study of prevention and control measures. [0003] Radiation enteritis (RE) is a common intestinal complication caused by radiotherapy for pelvic and abdominal malignant tumors, and there is still no effective clinical treatment. Cervical cancer is the second most common tumor occurring in women all over the world after breast cancer. It ranks first among female malignant tum...

Claims

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Application Information

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IPC IPC(8): A61N5/10
Inventor 张忠新蔺素琴董娟聪周晋源任越原雅艺张睿凤王超刘红艳左雅慧
Owner CHINA INST FOR RADIATION PROTECTION
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