Establishment method of mouse acute radiation duodenitis model

Abstract

The invention belongs to the technical field of radiation medicine, and specifically relates to a method for building a mouse acute radiation duodenitis model. According to the method, 8Gy gamma-ray irradiation is performed on mice, the irradiation part is the abdomen, duodenitis pathological analysis is performed on the mice after two weeks since the irradiation is conducted, and the protein expression levels of an apoptosis related factor BCL-2 and an inflammation related factor TGF-beta1 are detected. According to the invention, an irradiation method which is closer to clinical radiotherapyis adopted to build the radiation duodenitis model, thereby providing an experimental basis for prevention and treatment research for clinical radiation intestinal injuries.

Description

technical field

[0001] The invention belongs to the technical field of radiation medicine, and in particular relates to a method for establishing a mouse model of acute radiation-induced duodenitis. Background technique

[0002] The animal model of human disease is an animal experiment object with the simulated performance of human disease. The use of animal model is a very important experimental method in modern biomedical scientific research, which helps to understand the occurrence and development of human disease more conveniently and effectively. Law, so as to provide an experimental basis for the study of prevention and control measures.

[0003] Radiation enteritis (RE) is a common intestinal complication caused by radiotherapy for pelvic and abdominal malignant tumors, and there is still no effective clinical treatment. Cervical cancer is the second most common tumor occurring in women all over the world after breast cancer. It ranks first among female malignant tum...

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