Application of sulfated chlorella and spirulina composite polysaccharides in immunoloregulation field

A technology of compound polysaccharide and sulfated esterification, which can be applied to medical preparations, drug combinations, organic active ingredients and other directions containing active ingredients, and can solve problems such as immunomodulatory activity that has not yet been found.

Inactive Publication Date: 2018-01-26
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Through the search, there is no research on the combination of spirulina and chlorella for immunomodulatory activity

Method used

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  • Application of sulfated chlorella and spirulina composite polysaccharides in immunoloregulation field
  • Application of sulfated chlorella and spirulina composite polysaccharides in immunoloregulation field
  • Application of sulfated chlorella and spirulina composite polysaccharides in immunoloregulation field

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Embodiment Construction

[0020] The present invention will be described in further detail below with reference to the drawings and specific embodiments. The following embodiments are only descriptive and not restrictive, and the protection scope of the present invention cannot be limited by this.

[0021] Experimental Materials

[0022] Test polysaccharides: sulfated chlorella and spirulina complex polysaccharides, prepared in our laboratory, spirulina pure polysaccharide (PSP), provided by Shanghai Wenzhu Biotechnology Co., Ltd.

[0023] Test cells: mouse mononuclear macrophage cell line RAW264.7, standard cryopreserved products, mouse peritoneal macrophages, mouse spleen lymphocytes provided by Tianjin Kangsino Biotechnology Co., Ltd., prepared by our laboratory before the experiment.

[0024] Test animals: Kunming mice, SPF grade, healthy, half male and half male, 80, provided by Experimental Animal Center of Beijing Academy of Military Medical Sciences (Experimental Animal Production License Number: SCXK (...

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Abstract

The invention relates to an application of sulfated chlorella and spirulina composite polysaccharides in the immunoloregulation field. The sulfated composite polysaccharides have immunoloregulation activity, can enhance the neutral red phagocytosis ability of macrophages in mice, can improve the NO production ability of the macrophages and significantly improve the proliferation of splenic lymphocytes in the mice, and can improve the DNFB induced delayed allergy of the mice to enhance the immunity of the mice.

Description

Technical field [0001] The invention belongs to the field of marine biological applications, and relates to chlorella and spirulina, in particular to the application of sulfated chlorella and spirulina complex polysaccharides in the field of immune regulation. Background technique [0002] The growth conditions and environmental characteristics of microalgae determine that its intracellular polysaccharides have some structures and functions that are different from other biological polysaccharides. The application potential of such polysaccharides in the fields of medicine and medicine has attracted more and more research interest. However, in recent years, a large number of studies have found that polysaccharides from different sources of microalgae have different biological activities, and the biological activity of a single polysaccharide cannot fully enhance the body's immunity. [0003] Spirulina platensis is a kind of low-level ancient organisms, belonging to Cyanophyta (Cyano...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P37/02
Inventor 宋东辉
Owner TIANJIN UNIV OF SCI & TECH
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