A compound DICTYOPTERISINF and applications thereof in preparation of anti-tumor medicines
An anti-tumor drug and technology for anti-tumor effect, applied in the field of medicine, can solve the problem of unreported anti-tumor activity
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Embodiment 1
[0025] Embodiment 1: the preparation of described pterosin F
[0026] 1. Preparation of Reticula wavy extract extract
[0027] (1) Preparation of extract
[0028] 1.8 kg (wet weight) of frozen D. undulata (collected from the coast of Zhanjiang, Guangdong) were extracted three times by percolation with 5L 95% ethanol, each percolation for 2 days, and the extracts were combined;
[0029] (2) Preparation of extract extract
[0030] Concentrate the above extract under reduced pressure at a temperature of ≤45°C to recover ethanol to obtain 174.5 g of crude extract;
[0031] 2. Separation and purification
[0032] 1) Disperse the above crude extract in 2L of water to form a suspension, extract the suspension with ether (1.5L) four times, and concentrate the obtained extract under reduced pressure to obtain ether extract (54.3g);
[0033] 2) The diethyl ether extract was subjected to silica gel column chromatography, followed by petroleum ether / acetone and dichloromethanol / methan...
Embodiment 2
[0047] Embodiment 2: The in vitro antitumor activity test of the reticectin F
[0048] Cell lines: human acute promyelocytic leukemia cells (HL-60) and human lung cancer cells (A-549).
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