An extract rich in benzopyranolactone, its preparation method and its medicinal use

A technology of benzopyranolactone and extract, which is applied in the field of medicine, can solve the problems of high cost and increase the difficulty of monomer purification, and achieve the effects of low cost, reduced nephrotoxicity and high content
CN107987089BActive Publication Date: 2018-09-04南京道尔医药研究院有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
南京道尔医药研究院有限公司
Publication Date
2018-09-04

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Abstract

The invention discloses an extract enriched in benzopyran lactone as well as a preparation method and medical application of the extract. The extract provided by the invention is enriched in gastrodinA, gastrodin B and gastrodin C, wherein the sum of contents of the three is not lower than 90%; or the extract is enriched in gastrodin A, gastrodin B, gastrodin C and gastrodin D, and the sum of contents of the four is not lower than 85%. The extract is clear in monomer composition, high in content and capable of easily controlling the quality, the renal toxicity of aristolochic acid can be reduced, and the extract can be used for preparing a single Chinese herb containing aristolochic acid or a traditional Chinese medicine tract or an attenuated drug of a traditional Chinese medicine compound preparation. According to the preparation method of the extract, disclosed by the invention, separation methods that are difficult to operate on a large scale in a factory, such as column chromatography on silica gel, do not need to be repeatedly used, the extract with the total content 85% or higher of effective monomer composition can be prepared by only passing through a primary macroporousresin and combining with pH regulation and control, and the preparation method is capable of easily realizing industrialization, simple in operation and low in cost.
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Description

technical field

[0001] The invention belongs to the field of medicine, and relates to an extract rich in benzopyranolactone, a preparation method and a medical application. Background technique

[0002] Ligastrodin A, Ligastrodin B, Ligastrodin C, and Ligastrodin are the first benzopyranolactone compounds isolated from the root of Ligusticum sativa, and their chemical structures are shown in the table below.

[0003]

[0004] The applicant has found that peturogastrodin A, peturogastrodin B, peturogastrodin C, and peturogastrodin can reduce the nephrotoxicity of aristolochic acid, and can be used to prepare single Chinese medicine or Chinese medicine extract containing aristolochic acid or Attenuated drugs of traditional Chinese medicine compound preparations (see the invention patent application submitted by the applicant, the application number is 2017112638286).

[0005] However, from the above chemical structure, it can be known that petrogastrodin A, petrogastrodin ...

Claims

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