Anti-tumor pharmaceutical solution, pharmaceutical combined drug containing same and application method

Abstract

The invention belongs to the field of medicine and relates to a pharmaceutical combined solution with an anti-tumor effect, a pharmaceutical combination compound containing the pharmaceutical combinedsolution or a combination drug. The pharmaceutical combined solution, the pharmaceutical combination compound or the combination drug contains deuterium oxide, is utilized with methods of perfusion lavage, hyperthermic perfusion lavage, intravenous injection, arterial intervention injection, intrathecal injection, intratumoral and peritumoral injection and the like, is applied to oncotherapy andconvenient to use and has few toxic and side effects.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to an anti-tumor medicinal solution, a combination medicine containing it, a medicinal composition and usage Background technique [0002] According to the statistics report of the World Health Organization, in 2014, there were 12 million cases of malignant tumors worldwide and 8.5 million deaths. Therefore, it is a difficult and urgent task for medical workers to effectively control malignant tumors. [0003] At present, surgery, radiotherapy and various antineoplastic drug chemotherapy are mainly used to treat malignant tumors. These methods have their own characteristics, but they all have certain limitations. Especially when antineoplastic drugs are used for chemotherapy, the drug effect is often not obvious. For example, the clinical single-drug effective rate of commonly used antineoplastic drug 5-fluorouracil (5-FU) is only 10%. And many antineoplastic drugs have obvious toxicity. To...

AI Technical Summary

Problems solved by technology

This deuterium oxide oral solution has serious defects: 1) the current clinically effective antitumor treatment is multiple antitumor drugs combined with chemotherapy, but most antitumor drugs cannot be taken orally for various reasons, so it is difficult to combine deuterium oxide with many antitumor drugs. Drugs are used in combination, and it is impossible to perform combined chemotherapy to effectively treat patients; 2) each person has a different amount of free drinking water, and deuterium oxide is freely taken orally. The dosage cannot be quantified, and the therapeutic effect of different people cannot be compared. Influenced by pharmacokinetic factors such as absorption and metabolism, the intake is large and the drug effect is limited, and the possibility of becoming a drug is small; 3) The patient needs to drink a large amount of deuterium oxide in a short period of time, which is difficult to take, the clinical compliance is poor, and the cost is also high; 4) Many advanced cancer patients have had dysphagia or gastrointestinal surgery, unable to eat or drink, let alone take deuterium oxide orally

A temperature above 40°C can cause a series of physiological and immune antibody changes in the body, which can help increase the efficacy of anti-tumor drugs, but high temperatures can cause human damage. The best temperature range is to increase the efficacy of anti-tumor drugs without causing human damage. , still needs to be studied in detail

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