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Absorbable gelatin hemostatic powder and preparation method thereof

A technology of hemostatic powder and gelatin, which is applied in the fields of medical formula, surgery, drug delivery, etc. It can solve the problems of product safety impact, tissue irritation and carcinogenicity, etc., and achieve good hemostasis, avoid irritation, and simple process.

Active Publication Date: 2021-08-31
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Finally, the cross-linking agent will exist in the final product and will be gradually released during the subsequent degradation process of the gelatin material, causing tissue irritation and even possible carcinogenicity, which will affect the safety of the product

Method used

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  • Absorbable gelatin hemostatic powder and preparation method thereof
  • Absorbable gelatin hemostatic powder and preparation method thereof
  • Absorbable gelatin hemostatic powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A preparation method of absorbable hemostatic powder, comprising the steps of:

[0042] S1. Take 40g of existing gelatin, add 60g of water, place in an oven at 80°C until the gelatin is completely dissolved, and prepare an aqueous gelatin solution with a mass concentration of 40%;

[0043] S2. Take 1.6g of water-soluble carbodiimide (EDC) and dissolve it in 10ml of purified water (the mass of EDC is 4% of the mass of gelatin), add a cross-linking agent while stirring in the aqueous gelatin solution, and carry out cross-linking treatment, wherein the mechanical The stirring speed is 1000r / min, and the adding speed of the crosslinking agent is 2mL / s;

[0044] S3. placing the cross-linked gelatin in water to fully swell;

[0045] S4. The gelatin swollen in step S3 is divided into small pieces, and then it is pulverized into micron-sized gelatin particles by an aqueous phase material pulverizer;

[0046]S5. Place the gelatin particles in pure water for ultrasonic-centrifu...

Embodiment 2

[0050] A preparation method of absorbable hemostatic powder, comprising the steps of:

[0051] S1. Take 20g of existing gelatin, add 80g of water, place in a 50°C oven until the gelatin is completely dissolved, and prepare an aqueous gelatin solution with a mass concentration of 20%;

[0052] S2. Take 2 g of water-soluble carbodiimide (EDC) and dissolve it in 10 ml of purified water (the quality of EDC is 10% of the quality of gelatin), add a cross-linking agent while stirring in the aqueous gelatin solution, and carry out cross-linking treatment. The stirring speed is 2000r / min, and the addition speed of the crosslinking agent is 5mL / s;

[0053] S3. placing the cross-linked gelatin in water to fully swell;

[0054] S4. The gelatin swollen in step S3 is divided into small pieces, and then it is pulverized into micron-sized gelatin particles by an aqueous phase material pulverizer;

[0055] S5. Put the gelatin particles in pure water for ultrasonic-centrifugal cycle treatment...

Embodiment 3

[0058] A preparation method of absorbable hemostatic powder, comprising the steps of:

[0059] S1. Take 5g of existing gelatin, add 95g of water, place in a 50°C oven until the gelatin is completely dissolved, and prepare an aqueous gelatin solution with a mass concentration of 5%;

[0060] S2. Take 0.5 g of water-soluble carbodiimide (EDC) and dissolve it in 10 ml of purified water (the mass of EDC is 10% of the mass of gelatin), add a cross-linking agent while stirring in the aqueous gelatin solution, and carry out cross-linking treatment, wherein The rotational speed of the mechanical stirring of the gelatin solution is 2000r / min, and the addition speed of the crosslinking agent is 5mL / s;

[0061] S3. placing the cross-linked gelatin in water to fully swell;

[0062] S4. The gelatin swollen in step S3 is divided into small pieces, and then it is pulverized into micron-sized gelatin particles by an aqueous phase material pulverizer;

[0063] S5. The crushed gelatin particl...

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Abstract

The invention provides an absorbable gelatin hemostatic powder and a preparation method thereof, wherein the BET specific surface area of ​​the gelatin hemostatic powder is 30m 2 / g~70m 2 / g, and its preparation process includes the steps of cross-linking gelatin, water-absorbing swelling, mechanical pulverization, freeze-drying and secondary pulverization. The hemostatic powder can be well attached to the wound surface, quickly absorb the water in the blood, and achieve good hemostasis effect. Moreover, the preparation method has a simple process, further by adopting a cross-linking agent that does not participate in the reaction, and performing mechanical pulverization, ultrasonic-centrifugal cycle cleaning or ethanol aqueous cleaning operation after the gelatin is cross-linked and fully swollen, the cross-linking agent is effectively removed, The cross-linking agent has no residue in the hemostatic powder, avoids the irritating effect of the cross-linking agent on organisms, improves the safety of the product, and has good promotion and application value.

Description

technical field [0001] The invention relates to the technical field of hemostatic materials, in particular to an absorbable gelatin hemostatic powder and a preparation method thereof. Background technique [0002] Surgical hemostasis is one of the important steps in clinical operations. Good hemostasis techniques and materials are the key to ensure the success of the operation. At present, commonly used hemostatic materials include hemostatic sponge, hemostatic gauze, hemostatic gel, hemostatic powder, etc. Among them, the hemostatic powder is not affected by the size and location of the wound, and can be used not only for surgical wounds, but also for microscopic wounds such as endoscopes. Invasive surgery has unique advantages. [0003] In the prior art, the powdery hemostatic material is mainly a microporous polysaccharide product made of starch, and the polysaccharides on the surface of the starch granules are realized by ultrasonic method, wet heat treatment, microwave...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/10A61L24/00C08J3/24C08J3/07C08J3/12C08J9/28C08L89/00
CPCA61L24/00A61L24/104A61L2400/04C08J3/07C08J3/12C08J3/24C08J9/28C08J2201/0484C08J2207/10C08J2389/00C08L89/00
Inventor 马骋张馨之邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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