Use of citrus fruit volatile oil and medicines containing citrus fruit volatile oil

A technology of citrus and volatile oil, applied in the direction of medical preparations containing active ingredients, applications, drug combinations, etc., to achieve the effects of improving prostatitis, relieving climacteric syndrome, and improving hypothyroidism

Active Publication Date: 2021-08-10
河北成弘生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, there is no report on the use of citrus fruit volatile oil for endocrine regulation to relieve primary dysmenorrhea, relieve menopausal syndrome, improve hypothyroidism, and improve endocrine diseases such as prostatitis

Method used

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  • Use of citrus fruit volatile oil and medicines containing citrus fruit volatile oil
  • Use of citrus fruit volatile oil and medicines containing citrus fruit volatile oil
  • Use of citrus fruit volatile oil and medicines containing citrus fruit volatile oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] This example provides the animal experiment verification of citrus fruit volatile oil for alleviating primary dysmenorrhea function:

[0023] Animal grouping and modeling method: 48 female SD rats were weighed after adaptive feeding for 5 days, tail blood was taken, and prostaglandin E was measured 2 (PGE 2 ), prostaglandin F 2α (PGF 2α ), and according to the ratio of the two prostaglandins, the rats were randomly divided into 6 groups, 8 in each group, respectively blank control group, model control group, positive control group, low-dose group, middle-dose group, high-dose group From the 4th day onwards, each group was intragastrically administered according to the dose at 9:00 a.m. every day for 8 consecutive days. Each group was subcutaneously injected at 10 o'clock every day for 10 consecutive days starting from 1 day. The blank control group was injected with normal saline, and the rest of the groups were injected with estradiol benzoate injection. 10d1.0mg / r...

Embodiment 2

[0041] The present embodiment provides a method for preparing food and medicine containing citrus fruit volatile oil, comprising the following steps:

[0042] Step 1: Extraction of volatile oil: after cleaning the fresh citrus fruit, cut off the pericarp, cut the pericarp into small pieces of 8mm×8mm×8mm, extract the volatile oil by steam distillation for 2 hours at a material-to-liquid ratio of 1:4, collect the volatile oil and Add anhydrous sodium sulfate for dehydration, and filter to obtain citrus fruit volatile oil. Preferably, the citrus fruit can be sweet orange, pomelo, grapefruit, tangerine or bergamot.

[0043] Step 2: After mixing the citrus fruit volatile oil and starch octenyl succinate solution in a mass ratio of 1:4, high-speed shearing at 4000r / min, homogenization at 25MPa, and preparation of citrus fruits by spray drying Volatile oil powder grease, spray drying conditions are inlet air temperature 190°C, outlet air temperature 90-100°C, sample injection speed...

Embodiment 3

[0060] The present embodiment provides a method for preparing capsules containing citrus fruit volatile oil, comprising the following steps:

[0061] Step 1: Extraction of volatile oil: fresh citrus fruit, cut off the pericarp, cut the pericarp into small pieces of 8 mm × 8 mm × 8 mm, extract by steam distillation for 2 hours at a material-to-liquid ratio of 1:4, collect the volatile oil and add Dehydrated with sodium sulfate, filtered to obtain citrus fruit volatile oil.

[0062] Step 2: Glycerin, gelatin and water are prepared into capsule skins by conventional pharmaceutical methods, and the weight ratio of glycerin, gelatin and water is 5:2:6, and the above-mentioned citrus fruit volatile oil is placed in the capsule skins.

[0063] Preferably, the citrus fruit is sweet orange, pomelo, grapefruit, tangerine and bergamot.

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Abstract

The invention discloses the application of citrus fruit volatile oil in the preparation of foods and medicines for regulating endocrine to relieve primary dysmenorrhea, relieve menopausal syndrome, improve hypothyroidism, and improve prostatitis. It provides a new way to relieve primary dysmenorrhea, relieve climacteric syndrome, improve hypothyroidism, and improve prostatitis and other endocrine diseases.

Description

technical field [0001] The present invention relates to the application of citrus fruit volatile oil and medicine containing citrus fruit volatile oil. Background technique [0002] Citrus (scientific name: CitrusL.), a genus of Rutaceae. Often called citrus. The main feature is that the berry has a special structure, so it is also called citrus fruit. The oil spots on the exocarp are also called oil cells. The innermost layer of the mesocarp is a white linear network structure called orange white or orange network. After the skin matures, it is called the scoop sac. The cells on the inner wall of the scoop sac develop into spindle-shaped translucent crystal-like meat strips called juice cells. The juice cells often have a slender stalk. [0003] At present, the main use of citrus fruit volatile oil is to treat gastrointestinal problems. It can reconcile the stomach, stimulate gastrointestinal peristalsis, and help exhaust gas; it can also calm the digestive tract, increas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61P15/00A61P15/12A61P13/08A61P5/14A23L33/105A23G3/48A61K131/00
CPCA23G3/48A23V2002/00A61K36/752A61K2236/331A23L33/105A23V2200/30
Inventor 杨达
Owner 河北成弘生物科技有限公司
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