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Applications of long chain non-coding RNA and composition thereof in diagnosis/treatment of stomach cancer

A long-chain non-coding and compositional technology, which is applied in DNA/RNA fragments, drug combinations, recombinant DNA technology, etc., and can solve problems such as poor prognosis

Inactive Publication Date: 2018-07-13
NANJING PUKOU CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The rapid progression and metastasis of the disease lead to poor prognosis

Method used

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  • Applications of long chain non-coding RNA and composition thereof in diagnosis/treatment of stomach cancer
  • Applications of long chain non-coding RNA and composition thereof in diagnosis/treatment of stomach cancer
  • Applications of long chain non-coding RNA and composition thereof in diagnosis/treatment of stomach cancer

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Embodiment Construction

[0033] The present invention is further illustrated below with examples, but the present invention is not limited thereto. For the experimental methods without specific conditions indicated in the following examples, the conventional conditions or the conditions suggested by the manufacturer are usually followed.

[0034] 1. Organization collection

[0035] Based on histopathological analysis (according to the "Seventh Edition AJCC Cancer Staging Manual"), we collected 42 patients with gastric cancer who received diagnosis and surgical treatment in Jiangsu Provincial People's Hospital from 2006 to 2008. Tissue samples were collected first in liquid nitrogen or stored at -80°C until RNA extraction. This study was approved by the Ethics Committee of Nanjing Medical University. Written informed consent was obtained from all patients.

[0036] 2. Experimental equipment and reagents

[0037] Experimental methods and research techniques used in the present invention: as extracti...

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Abstract

The invention belongs to the field of gene engineering, and especially relates to applications of a long chain non-coding RNA, NFIA-AS1, and a composition thereof in preparation of drugs used for diagnosis of stomach cancer and target drugs of stomach cancer. The invention also relates to a primer of the long chain non-coding RNA, and applications of the primer in preparation of reagents used fordiagnosis of stomach cancer. The relation of the long chain non-coding RNA with stomach cancer morbidity mechanisms are revealed through study on cell level expression of the long chain non-coding RNA.

Description

technical field [0001] The invention belongs to the field of genetic engineering, and particularly relates to a long-chain non-coding RNA, NFIA-AS1 and its composition, and its application in the preparation, diagnosis and target drug treatment of gastric cancer. Simultaneously, the present invention also relates to the application of the primers in the preparation of reagents for diagnosing gastric cancer. Background technique [0002] Gastric cancer (GC) is the second leading cause of cancer death worldwide. The rapid progression and metastasis of the disease lead to poor prognosis. To improve the early diagnosis and targeted therapy of GC, there is an urgent need to understand its underlying molecular mechanism and identify novel and effective novel biomarkers and therapeutic targets. [0003] Long non-coding RNAs (lncRNAs) are a class of RNA molecules with a transcript length of more than 200 nt, which are different from other small non-coding RNAs in that they can reg...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886A61K45/00A61P35/00C12N15/11
CPCA61K45/00C12Q1/6886C12Q2600/158C12Q2600/178
Inventor 陆志斌
Owner NANJING PUKOU CENT HOSPITAL
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