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A kind of medicine box and application thereof for malignant tumor immunotherapy

An immunotherapy drug, a technology for malignant tumors, applied in the field of medicine, can solve the problems of no tumor treatment, functional inhibition, and unclear mechanism of action of traditional Chinese medicine.

Active Publication Date: 2021-04-30
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both use intestinal probiotics as carriers, and traditional Chinese medicine or traditional Chinese medicine components as active substances to achieve the purpose of treating tumors or anti-cancer. After the carrier is combined with traditional Chinese medicine, its own functions may be inhibited
Chinese patent document 201180055177.6 discloses an improved oral targeted drug delivery system. The drug used in this patent is 5-fluorouracil, which can easily cause microbiota disturbance during conventional medication. Combining it with intestinal probiotics can overcome the negative effects of the drug. The function of Dao probiotics is only to regulate the ecological balance of the microbial community, but not to treat tumors, and after intestinal probiotics are used as carriers and combined with drugs, the functions of intestinal probiotics themselves may be inhibited

Method used

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  • A kind of medicine box and application thereof for malignant tumor immunotherapy
  • A kind of medicine box and application thereof for malignant tumor immunotherapy
  • A kind of medicine box and application thereof for malignant tumor immunotherapy

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Experimental program
Comparison scheme
Effect test

Embodiment

[0036] Embodiment: pharmacological test

[0037] 1. Materials and methods

[0038] 1.1 Test animals

[0039] Animals: Balb / c mice, male, 6-8 weeks old, 18±2g.

[0040] 1.2 Model establishment

[0041] Take H22 mouse liver cancer cells in good growth state and logarithmic growth phase, digest the cells with 0.25% trypsin to make them into single cells, wash twice with PBS, adjust the cell concentration to 2 with normal saline by cell counting method ×10 7 cell / ml, each healthy Balb / c male mouse was subcutaneously inoculated with 0.1ml (containing 2×10 6 During the feeding process, the mice in each group were given the same diet, and the relative humidity in the animal room was kept at 20-30%.

[0042] 1.3 Grouping and administration

[0043] Control group: intragastric administration of normal saline, once a day, for 22 consecutive days;

[0044] Intervention group 1: The daily oral dose of LY2157299 is 1.5 mg, and the oral administration is continued for 22 days;

[00...

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Abstract

The invention discloses a medicine kit for immunotherapy of malignant tumors and an application thereof. The medicine kit includes a preparation containing a transforming growth factor-β receptor inhibitor and a preparation containing intestinal probiotics; the transforming growth factor-beta receptor The weight ratio of body inhibitors to the intestinal probiotics is 1:166-1:1111. Pharmacological studies have confirmed that the kit of the present invention has the functions of controlling tumor growth, reducing tumor burden, promoting the maturation and differentiation of dendritic cells and cytotoxic T cells, and regulating the immune microenvironment of tumors, and can be applied to the immunotherapy of various malignant tumors.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a medicine box for immunotherapy of malignant tumors and the application of the medicine box in immunotherapy of malignant tumors. Background technique [0002] Tumor is the product of malignant transformation of normal cells in the body, which is characterized by continuous proliferation and metastasis in the body. Under normal circumstances, the body's immune system can recognize and eliminate tumor cells in the tumor microenvironment, but in order to survive and reproduce, tumor cells can adopt different strategies to suppress the body's immune system and cannot normally recognize and kill tumor cells. Thus surviving all stages of the anti-tumor immune response. Tumor immunotherapy is a treatment method to control and eliminate tumors by restarting and maintaining the tumor-immune cycle and restoring the body's normal anti-tumor immune response. [0003] In recent years, with the imp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/741A61K31/4709A61P35/00A61K35/744A61K35/745A61K35/747A61K35/74
CPCA61K31/4709A61K35/74A61K35/741A61K35/744A61K35/745A61K35/747A61P35/00A61K2300/00
Inventor 刘智杨祥良石林林盛剑勇陈国忠张白
Owner HUAZHONG UNIV OF SCI & TECH
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