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Application of LTA4H as biomarker for indicating intrahepatic nodule and pre-warning liver cancer at early stage

A molecular marker and nodule technology, applied in the fields of biomaterial analysis, instruments, measurement devices, etc., can solve problems such as affecting the quality and effect of treatment, affecting the understanding of the disease, and patient trauma.

Inactive Publication Date: 2018-11-02
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI +1
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Problems solved by technology

However, these diagnostic methods have drawbacks. On the one hand, the disease is extremely serious and the tumor has grown large enough to be distinguished by medical imaging equipment;
These diagnostic deficiencies seriously affect the understanding of the disease and thus affect the quality and effectiveness of treatment

Method used

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  • Application of LTA4H as biomarker for indicating intrahepatic nodule and pre-warning liver cancer at early stage
  • Application of LTA4H as biomarker for indicating intrahepatic nodule and pre-warning liver cancer at early stage
  • Application of LTA4H as biomarker for indicating intrahepatic nodule and pre-warning liver cancer at early stage

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[0037] It should be understood that within the scope of the present invention, the above-mentioned technical features of the present invention and the technical features specifically described in the following (such as embodiments) can be combined with each other to form a preferred technical solution.

[0038]In order to imitate as much as possible the process of malignant transformation of inflammation and cancer caused by both endogenous and exogenous influences, this paper used c-myc transgenic mice that developed hepatitis to liver cancer under the infection of woodchuck hepatitis virus (WHV). Animal models of disease. Previous studies (Etiemble J, Degott C, Renard CA, etc., Liver-specific expression and high oncogenic efficiency of a c-myc transgene activated by woodchuck hepatitis virus insertion, Oncogene 1994, 9:727-737) showed that during the development of liver cancer In the study, the liver of WHV / c-myc mice has successively experienced pathological processes such...

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Abstract

The invention relates to application of LTA4H as a biomarker for indicating an intrahepatic nodule and pre-warning liver cancer at an early stage, in particular to application of the following reagents in preparing a kit for diagnosing the intrahepatic nodule of an object or diagnosing whether the object is in a vicious transformation critical phase from hepatitis to liver cancer, and the reagents comprise: (1) a reagent which is specifically combined with LAT4H; (2) a reagent which is specifically combined with PLA2G6; and (3) a reagent which is randomly selected and specifically combined with EPS8L2. The key critical stage of transformation from hepatitis to liver cancer is found based on an analysis on time sequence dynamics and network correlation, so that a novel direction is provided for being clinically applied to early-stage liver cancer treatment of a patient with hepatitis, judging whether the patient is in the critical stage of vicious transformation from hepatitis to liver cancer, and preventing deterioration of hepatitis and liver cancer.

Description

technical field [0001] The present invention relates to LTA4H as a biomarker for indicating intrahepatic nodules and early warning of liver cancer. Background technique [0002] Liver cancer, as one of the most life-threatening malignant tumors, has attracted worldwide attention. According to the global cancer statistics report, liver cancer has become the cancer with the highest incidence rate in China, and the rampant hepatitis virus has made China the hardest hit area for hepatitis and liver cancer. Therefore, how to effectively prevent the deterioration of hepatitis to liver cancer has become one of the important topics for domestic researchers. [0003] Recently, studies have shown that chronic inflammation can indeed induce the occurrence of various cancers, including liver cancer. Although researchers have put forward many hypotheses about the mechanism of inflammation promoting cancer, the mechanism of malignant transformation from chronic hepatitis to liver cancer...

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Application Information

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IPC IPC(8): G01N33/574G01N33/573
CPCG01N33/573G01N33/57438G01N33/57484G01N2333/914
Inventor 王红阳陈磊陈洛南曾嵘杨应成李辰李美仪刘伟鑫
Owner SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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