Intestinal flora reconstruction kit and its application

A technology of intestinal flora and kit, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, and unknown raw materials, etc., can solve the problem of unclear active ingredients of donor feces, cumbersome preparation and transplantation operations, and problems with fecal flora. Uncontrollable issues such as transplantation, to avoid errors or unreasonable use, fast re-establishment, and high security effects

Active Publication Date: 2020-04-03
HEBEI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sample preparation and transplantation operations for fecal microbiota transplantation are cumbersome, and oral fecal microbiota capsules are poorly accepted by patients, while other methods are painful for patients and costly
Moreover, because the active ingredients of donor feces are not clear, fecal microbiota transplantation brings uncontrollable risks
At present, there is no safe, efficient, and easy-to-accept method that can change the intestinal flora.

Method used

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  • Intestinal flora reconstruction kit and its application
  • Intestinal flora reconstruction kit and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] The method for using the intestinal flora reconstruction kit in the process of intestinal flora reconstruction comprises the following steps:

[0065]1) Day 1: For lunch and dinner, eat liquid food and non-dregs food, such as soft rotten bean porridge or oatmeal porridge, milk, custard, rye noodles, soy milk, etc. until you are 70 to 80% full.

[0066] 2) Day 2:

[0067] a: Breakfast: Before meals, take the compound polyethylene glycol electrolyte powder or mannitol injection in the nth chamber of the kit orally for colon lavage. After the colon lavage is completed, start eating after the intestines are emptied, and open the n+1 chamber In the room, take nutrition powder (35g individually packaged) and make porridge with hot water before taking it, and eat an appropriate amount of liquid food and vegetables that are cooked until soft and rotten until 70% full. Take the first meal within 0.5-1h after a meal Group A probiotics and group B probiotics in the n+1 chamber, t...

Embodiment 2

[0085] Application of intestinal flora reconstruction kit in diabetic intestinal flora reconstruction.

[0086] Gao, female, 68 years old, from Baoding, Hebei Province, was diagnosed with type II diabetes for 5 and a half years, with fasting blood sugar of 10-12 and postprandial blood sugar of 19-20. about.

[0087] On March 5, 2018, the intestinal flora reconstruction method was used to carry out the flora intervention program for conditioning, and the intervention was carried out according to the use of the intestinal flora reconstruction kit in Example 1, and metformin and Glide were stopped 4 days later Benurea, after testing, the fasting blood sugar was maintained at 5.5-6.7, and the intervention was stopped after two months of intervention, and the fasting blood sugar remained stable at 5.5-6.7.

[0088] The group A probiotics used in the kit during the flora intervention in this example include Bacillus coagulans, Bacillus cereus, Bacillus licheniformis, Enterococcus f...

Embodiment 3

[0093] Application of intestinal flora reconstruction kit in diabetic intestinal flora reconstruction

[0094] Li, male, 18 years old, from Shijiazhuang, Hebei, reported that type I diabetes had been diagnosed for 3 years. Insulin aspart 3 times a day × 8 units before flora reconstruction, insulin glargine 20 units a day (at night), fasting blood sugar 6-6.5.

[0095] On April 1, 2018, the method of using the intestinal flora reconstruction kit in Example 1 was used for intervention conditioning. Within 1-60 days of the intervention, except for the method of using the intestinal flora reconstruction kit in Example 1 At the same time of use, it is also combined with the use of insulin, and the amount of insulin is gradually adjusted through the detected blood sugar index. The process of insulin use and adjustment is as follows:

[0096] From April 2, insulin aspart 3 times a day × 7 units, insulin glargine 18 units per day (evening), measured on April 3 fasting blood sugar 5.8...

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Abstract

The invention discloses an intestinal flora reconstruction kit and application thereof. The kit comprises a kit body, which comprises a plurality of chambers opened sequentially and regularly, whereinthe chambers are an n chamber to an n+x chamber according to the opening sequence, the opening time interval between the adjacent chambers in an n+1 chamber to the n+x chamber is setas 4-12 hours; the nchamber contains compound polyethylene glycol electrolyte powder or mannitol injection; the n+1 chamber contains microecological preparation agents with group A and B; ann+2 chamber contains the microecological preparation agents with group B and C; an n+3 chamber to an n+33 chamber contain the microecological preparation agent with group A or B; and an n+34 chamber to the n+x chamber contains the microecological preparation agent with group B. Taking different preparation agents by washing intestines and taking the agents in different sequences is conducive to the rapid establishment of the intestinal flora. The invention further discloses an application of the kit in the reconstruction of diabetic intestinal flora, the flora reconstruction is conducive to regulating the blood glucose of patients, so that the reconstruction of intestinal flora is feasible in regulating the blood glucose of the diabetic patients.

Description

technical field [0001] The invention relates to the technical field of general health, more specifically, the invention relates to a kit for rebuilding intestinal flora and its application. Background technique [0002] The intestinal tract is the largest organ for digestion, absorption and excretion of the human body. More than 90% of the nutrients and metabolic waste in the human body are absorbed and excreted through the intestinal tract. In addition to the intestinal tract itself, there are more than 1,500 kinds of microorganisms living in the intestinal tract, which are 10 times the number of human cells. These microorganisms are mainly bacteria, forming an extremely complex group, which is the intestinal flora. A healthy intestinal flora is combined in a certain proportion. Various bacteria restrict and depend on each other. They have a symbiotic relationship with the host and jointly maintain the physiological homeostasis of the host. [0003] The establishment of th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B65D25/02A61K35/742A61K35/744A61K35/745A61K35/747A61K35/741A61P1/00
CPCA61K35/741A61K35/742A61K35/744A61K35/745A61K35/747A61P1/00B65D25/02A61K2300/00
Inventor 吕志堂
Owner HEBEI UNIVERSITY
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