Chemical health hazard screening method

A chemical and health technology, applied in the direction of instruments, calculations, electrical digital data processing, etc., can solve the health hazard screening of chemicals with NMF method, the screening and prediction method of health hazards of undeveloped exogenous chemicals , health hazard structure extrapolation and other issues

Active Publication Date: 2018-11-30
RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In 2010, Rappaport and Smith wrote an article in Science clearly pointed out that 70-90% of diseases are caused by the environment rather than genetic differences. However, although there is a consensus that chemical pollution can cause health risks, the possible health hazards caused by different chemicals are due to the different damage mechanisms. complexities have not yet been elucidated
[0007] To sum up, the structure-activity relationship prediction technology is difficult to accurately screen and predict the complex toxicity of chemicals, and the model based on pure biological information can simultaneously analyze and rank the effects of multiple organisms, but cannot

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chemical health hazard screening method
  • Chemical health hazard screening method
  • Chemical health hazard screening method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] In this embodiment, the chemical health hazard screening method based on the association analysis of structure and omics features includes the following steps:

[0092] (1) Network model construction of drug health effects associated with their chemical structural features and transcriptome features:

[0093] Download the drug gene microarray data provided by the public database CMap, and retain the drugs with accurate structures that can be obtained through the drug names. In order to eliminate the differences in data from different sources and experimental batches, the gene chip samples of four different cell lines were normalized and merged. Change value (Fold-Change, referred to as FC) and deviation value Δ, using Δ as the correction value, convert the FC of the corresponding genes of all chip samples in one batch to FC+Δ to achieve a merge, repeat the above operation, until all batches data merge. According to the calibrated FC value, the 1000 genes that were sig...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A chemical health hazard screening method mainly comprises the following steps: decomposing a known pharmacodynamic drug structure and transcriptomic characteristics by a non-negative matrix to establish a structure-health impact-transcriptomic association network model; conducting internal validation on the association network model from the aspects of the therapeutic effect and the structural similarity; obtaining a chemical health hazard screening criteria based on the structure matching degree of the determined drug efficacy and each health impact of the model; utilizing the chemical health hazard screening criteria for sorting and screening of chemical health hazards within a model application domain. According to the method, the pharmaconomics big data is utilized to establish an evaluation screening model that multiple health hazard rankings can be obtained by simply inputting a chemical structure, the difficulty that accurate prediction of complex toxicity and simultaneous screening of multiple health impacts cannot be achieved by simple structure similarity in the chemical health risk evaluation is overcome, and the method has wide application prospects in the chemical health risk evaluation field.

Description

technical field [0001] The invention relates to the technical field of chemical health hazard assessment, and more particularly relates to a method for screening chemical health hazards. Background technique [0002] At present, environmental safety and health problems caused by environmental chemical pollution are becoming increasingly prominent. Chemicals of different structural types have been detected in various environmental media and exposed populations. The "cancer villages" that have appeared in many places are closely related to pollution such as metals and organic substances. According to the cause of death survey data, the morbidity and mortality of major diseases such as malignant tumors are on the rise year by year. WHO pointed out that 21% of the medical burden of Chinese residents comes from environmental pollution factors. As early as 1996, the book "Our Stolen Future" pointed out the great threat of chemical pollution to human survival and reproduction. In ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G06F19/00
Inventor 刘娴张爱茜张华洲潘文筱薛峤
Owner RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products