A kind of quality control method of Changyanning Granules

Abstract

The invention belongs to the technical field of medical quality detection, and particularly discloses a quality control method of Changyanning granules. The quality control method includes the steps that thin layer chromatography is used for qualitative identification of a humifuse euphorbia herb in the Changyanning granules, and high performance liquid chromatography is used for determining the contents of active ingredient gallic acid of the humifuse euphorbia herb, hedyotis chrysotricha and folium liquidambaris in the Changyanning granules to be subjected to quantitative control. The quality control method of the Changyanning granules is simple, good in separation degree, high in specificity, good in reproducibility and high in content, the quality and curative effect of the Changyanning granules are effectively guaranteed, and high practicability is achieved.

Description

technical field [0001] The invention belongs to the technical field of medicine quality detection, and in particular relates to a quality control method of Changyanning granules. Background technique [0002] The prescription of Changyanning Granules is: Dijincao, Prunus chinensis, Camphor tree root, Lemongrass, and maple leaves. It has the functions of clearing away heat, promoting dampness, and promoting Qi. Indigestion, related preparations of Changyanning also include Changyanning syrup with the same formula as Changyanning granules. The quality control method of Changyanning syrup is recorded in the 2015 edition of Chinese Pharmacopoeia, specifically: [0003] (1) Identification of Dijincao: Take 15ml of this product, add 30ml of water, shake well, shake and extract 3 times with ether, 30ml each time, combine the ether solution, evaporate to dryness, add 1ml of methanol to the residue to dissolve, and use it as the test sample solution; take another 2 g of Dijincao ref...

AI Technical Summary

Problems solved by technology

[0005] However, the above quality control method is not applicable to Changyanning Granules. This is because Changyanning Granules and Changyanning Syrup are in different dosage forms, and there are big differences in the preparation methods. Quality control needs to be carried out according to different standards. For Changyanning Granules Refer to the above method to identify Dijincao, the negative has interference, and the result is unstable; the content of gallic acid is measured, it is also negative and has interference, and the content is low

[0006] However, Changyanning Granules are not included in the 2015 edition of Chinese Pharmacopoeia. The existing identification items for Changyanning Granules only include fluorescent identification of its aqueous solution, precipitation using lead acetate, ferric chloride chromogenic method, and scopoletin as a control. Carry out identification golden hair ear grass, and its identification method is simpler, and accuracy is poor, is difficult to guarantee the quality of Changyanning granule; In addition, existing Changyanning granule only adopts spectrophotometric method to measure content, selects total flavonoids as content determination index with rutin , but the specificity of spectrophotometry is not strong, the control results are not accurate enough, and it is also difficult to guarantee the quality of Changyanning Granules

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