33results about How to "Negative without interference" patented technology

The invention relates to a quality control method for a rhizoma gastrodiae capsule and belongs to the technical field of biomedicine. The quality control method comprises the steps of raw material control, preparation method control, an identification method and a content measurement method. Modern drug production management is integrated in quality control. The quality of drugs and solvents used in production is examined from the source. Product quality control in the production process is established, perfect product quality standards are established, the thin-layer chromatographic detection ratio is higher than national requirements, the gastrodin content is greatly increased, the increase degree reaches 28.3%, and the quality and the therapeutic effect of the drug product are ensured.

The invention discloses a quality control method of a loins-strengthening and kidney-invigorating medicine. In the method, beautiful millettia root, rhizoma cibotii, kadsura coccinea, caulis spatholobi, parasitic loranthus and glossy privet fruit in the medicine are respectively identified by a thin layer chromatography; and the content of protocatechuic acid and the content of protocatechuic aldehyde in the medicine are measured via a liquid chromatography. In the quality control method established by the invention, the medicine material identifying method is mature and feasible, strong in specificity, negative and interference-free; the content measurement method is easy in operation, high in precision and good in reproducibility; and by adopting the quality control method disclosed by the invention, the quality of the medicine can be precisely and stably controlled to adapt to the industrial and stable production of the medicine.

The invention provides a quality control method for an antirheumatic medicine. Besides the characters and inspection, the method also comprises the steps of identification, extract determination and assaying, wherein the identification step is to dissolve the content of the antirheumatic medicine--a rheumatalgia-relieving preparation in alcohol, carry out ultrasonic extraction to prepare a solution to be tested, prepare a comparison solution with the comparison crude drug of lilac daphne strips, and then carry out thin layer chromatographic comparison. The extract determination step is to carry out the alcohol backflow and leaching of the content of the antirheumatic medicine--the rheumatalgia-relieving preparation and determine the dry substance amount of the methanol extract. The assaying step is to carry out methanol backflow and leaching of the content of the antirheumatic medicine--the rheumatalgia-relieving preparation to prepare the solution to be tested, carry out the high pressure liquid chromatography detection together with the reference substance of daphnetin, and determine the content of the daphnetin in the content of the antirheumatic medicine--the rheumatalgia-relieving preparation. The method is suitable for the quality control of the antirheumatic medicine -the Rheumatalgia-relieving preparation including tablets, capsules, granules, pills, and the like.

The invention relates to a method for determining the content of Qianlieping capsules. Liquid chromatography is used to measure the content of luteolin in Qianlieping preparations. On the basis of the original standard, the high-performance liquid chromatography of luteolin in Junyao Beibaijiang is added. As for content determination, methodological investigation proves that the method has good precision and accuracy, and is negative without interference. The whole test process is highly operable and can be used as one of the indicators for controlling the internal quality of this product. The invention has strong specificity for the content detection of Beibaijiang, is simple, fast and reliable, can more effectively control the quality of Qianlieping capsules, makes the quality of Qianlieping capsules stable and controllable, and ensures curative effect, thereby better meeting the needs of medical treatment .

The invention provides a detection method of a medicine for treating epileptoid convulsion, infantile convulsion and mimic convulsion. The detection method comprises a step that Salvia miltiorrhiza in the medicine by adopting thin layer chromatography, wherein thin layer chromatography conditions are characterized in that a silica gel G thin layer plate is adopted, and an A-B-C mixed solution having an A / B / C volume ratio of 70-100:5-10:1-5, preferably 80-100:6-9:1-4, and more preferably 90:8:2 is adopted as a developing solvent; the above A solution is selected from dichloromethane, benzene, toluene, trichloromethane, isopropanol and n-butanol, and preferably trichloromethane; the above B solution is selected from ethanol, ethyl acetate, acetone, glycol, methanol and dioxin, and preferably methanol; and the above C solution is selected from formic acid, acetate acid gracial, dimethyl ether, methyl formate and water, and preferably formic acid. The method allows the quality of the medicine to be effectively controlled, and to be stable, controllable, efficient and safe.