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Detection method of Xianyu capsule for treating epileptoid convulsion, infantile convulsion and mimic convulsion

A technique for the detection of convulsions in children, which is applied in the field of capsules for the treatment of epileptic convulsions, convulsions in children, epilepsy capsules, and capsules for hemifacial spasm. It can solve the problems of not formulating other ingredients and achieve good sample reproducibility , The effect of stable and controllable quality

Active Publication Date: 2014-02-19
XIAN CHIHO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In the existing detection methods for epileptic convulsions, infantile convulsions, and hemifacial spasm, such as Xianyu Capsules, only Astragalus was identified by thin-layer chromatography (TLC), but other ingredients, especially Danshen, were not identified. Identification method

Method used

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  • Detection method of Xianyu capsule for treating epileptoid convulsion, infantile convulsion and mimic convulsion
  • Detection method of Xianyu capsule for treating epileptoid convulsion, infantile convulsion and mimic convulsion
  • Detection method of Xianyu capsule for treating epileptoid convulsion, infantile convulsion and mimic convulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1 Prescription and preparation method of Xianyu Capsule

[0051] prescription:

[0052]

[0053]

[0054] Preparation method: The above sixteen flavors, stiff silkworm, and Liushenqu are crushed into fine powder, sieved, and set aside; the other fourteen flavors such as astragalus are boiled in water for three times, the first time is 2 hours, the second time is 1.5 hours, and the third time is 1 hour. hours, combined the decoction, filtered, the filtrate was concentrated under reduced pressure to a thick paste with a relative density of 1.36 (60°C), added the above fine powder, mixed evenly, dried in vacuum, crushed into a fine powder, and granulated with 80% ethanol in an appropriate amount. Dry at 70°C, pack into capsules, and make 1000 capsules.

[0055] Properties: This product is a hard capsule, the contents are brown to tan granules and powder; taste bitter.

Embodiment 2

[0056] Example 2 TLC Identification of Salvia Miltiorrhiza in Xianyu Capsules

[0057] 1. Test conditions: double-layer expansion cylinder (Shanghai Xinyi); silica gel G (for thin-layer chromatography, Qingdao Ocean Chemical Factory); homemade thin-layer plate with a thickness of 0.3mm. The rest of the reagents were analytically pure.

[0058] 2. Test procedure: Take 10 g of the capsule content prepared in Example 1, add 35 ml of 70% ethanol, heat and reflux for 30 minutes, filter, evaporate the filtrate to dry without ethanol smell, add 20 ml of water to dissolve, add 1mol / L hydrochloric acid to adjust the pH to 1 -2, then shake and extract with ethyl acetate 3 times, 10ml each time, combine the ethyl acetate solution, evaporate to dryness, add 2ml of methanol to dissolve, and use it as the test solution.

[0059] Another protocatechualdehyde reference substance, add methanol to make a solution containing 0.5mg per 1ml, as the reference substance solution.

[0060] Then t...

Embodiment 3

[0065] Example 3 TLC Identification of Salvia Miltiorrhiza in Xianyu Capsules

[0066] 1. Test conditions: double-layer expansion cylinder (Shanghai Xinyi); silica gel G (for thin-layer chromatography, Qingdao Ocean Chemical Factory); homemade thin-layer plate with a thickness of 0.3mm. The rest of the reagents were analytically pure.

[0067] 2. Test procedure: Take 10 g of the capsule content prepared in Example 1, add 35 ml of 70% ethanol, heat and reflux for 30 minutes, filter, evaporate the filtrate to dry without ethanol smell, add 20 ml of water to dissolve, add 1mol / L hydrochloric acid to adjust the pH to 1 -2, then shake and extract with ethyl acetate 3 times, 10ml each time, combine the ethyl acetate solution, evaporate to dryness, add 2ml of methanol to dissolve, and use it as the test solution.

[0068] Another protocatechualdehyde reference substance, add methanol to make a solution containing 0.5mg per 1ml, as the reference substance solution.

[0069] Then t...

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Abstract

The invention provides a detection method of a medicine for treating epileptoid convulsion, infantile convulsion and mimic convulsion. The detection method comprises a step that Salvia miltiorrhiza in the medicine by adopting thin layer chromatography, wherein thin layer chromatography conditions are characterized in that a silica gel G thin layer plate is adopted, and an A-B-C mixed solution having an A / B / C volume ratio of 70-100:5-10:1-5, preferably 80-100:6-9:1-4, and more preferably 90:8:2 is adopted as a developing solvent; the above A solution is selected from dichloromethane, benzene, toluene, trichloromethane, isopropanol and n-butanol, and preferably trichloromethane; the above B solution is selected from ethanol, ethyl acetate, acetone, glycol, methanol and dioxin, and preferably methanol; and the above C solution is selected from formic acid, acetate acid gracial, dimethyl ether, methyl formate and water, and preferably formic acid. The method allows the quality of the medicine to be effectively controlled, and to be stable, controllable, efficient and safe.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a detection method for medicines for treating epileptic convulsions, infantile convulsions and hemifacial spasm, in particular to a capsule for treating epileptic convulsions, infantile convulsions and hemifacial spasm Agents, such as the detection method of Xianyu Capsules. Background technique [0002] Epilepsy, whether primary or secondary, can cause neuronal damage, mental decline, trauma, and even sudden and unexpected death. The most important purpose of treatment is to control seizures and maintain normal neuropsychiatric function, and the main means of controlling seizures is drug treatment. Surgical treatment should be considered for patients with definite lesions, drug treatment ineffective or unacceptable side effects. [0003] Convulsion is an emergency in children complicated by various diseases. Modern medicine is generally treated separately accordi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/90A61K36/9066A61K9/48A61P25/08A61P25/02A61K35/64
Inventor 胡小虎赵宗平
Owner XIAN CHIHO PHARMA
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