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Quality detection method of capsule for reducing blood fat and activating collaterals

A quality inspection method and a technique for penetrating the pulse, which can be used in measuring devices, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as insufficient specificity and low level of product quality control.

Inactive Publication Date: 2011-07-27
唐秋海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing Jiangzhitongmai Capsules quality standard only stipulates the TLC identification of Semen Cassiae and Panax notoginseng in the prescription, and uses high performance liquid chromatography to determine the ginsenoside Rg1 (C 42 h 72 o 14 ), the specificity is not strong enough, and the quality control level of the product is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The quality testing method of Jiangzhitongmai Capsules is as follows:

[0018] 1. Identification:

[0019] (1) Take 8g of the content of this product, add 30ml of methanol, soak for 1 hour, filter, evaporate the filtrate to dryness, add 30ml of water to dissolve the residue, add 3ml of hydrochloric acid, heat and reflux for 30 minutes, let cool, shake and extract with ether three times , 30ml each time, combined ether solution, evaporated to dryness, added 2ml of chloroform to the residue to dissolve, and used it as the test solution; in addition, 1g of cassia seed control medicinal material was used to prepare the contrast medicinal material solution with the method of the above-mentioned test solution; then take emodin and chrysophanol reference substance, add methanol to make a mixed solution containing 1mg per 1ml, as the reference substance solution; according to the test of thin layer chromatography (Appendix VI B of the Chinese Pharmacopoeia 2010 edition), absorb...

Embodiment 2

[0028] 1. Identification:

[0029] (1) and (2) steps are the same as in Example 1, omitted.

[0030] (3) Take 2g of the content of this product, add methanol 45ml, sonicate for 20 minutes, filter, evaporate the filtrate to dryness, add 1.5 ml of methanol to dissolve the residue, and use it as the test solution; 19.5 ml, use the same method as the content to prepare the control medicinal material solution; draw 3-10 μl of each of the above two solutions, and spot them on the same silica gel G thin-layer plate, and use n-hexane-ethyl acetate (5.5: 0.5) as the Developing agent, unfold 12 cm, take it out, dry it, spray 10% ethanol sulfuric acid solution in volume percentage concentration, blow hot air until the spots are clearly colored, and inspect them under fluorescent lamp and ultraviolet lamp respectively. On the corresponding position, the spots of the same color are displayed.

[0031] All the other steps are the same as in Example 1.

Embodiment 3

[0033] 1. Identification:

[0034] (1) and (2) steps are the same as in Example 1, omitted.

[0035] (3) Take 2 g of the content of this product, add 55 ml of methanol, ultrasonicate for 20 minutes, filter, evaporate the filtrate to dryness, add 2.5 ml of methanol to dissolve the residue, and use it as the test solution; Methanol 20.5 ml, use the same method as the content to prepare the control medicinal material solution; absorb 3-10 μl of each of the above two solutions, and spot them on the same silica gel G thin-layer plate, and use n-hexane-ethyl acetate (6.5:1.5) As a developing agent, expand 16 cm, take it out, dry it, spray it with 10% ethanol sulfuric acid solution in volume percent concentration, and blow it with hot air until the spots are clearly colored, and inspect them under fluorescent lamp and ultraviolet lamp respectively. On the corresponding position of the color spectrum, the spots of the same color are displayed.

[0036] All the other steps are the sa...

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PUM

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Abstract

The invention discloses a quality detection method of a capsule for reducing blood fat and activating collaterals. The capsule for reducing blood fat and activating collaterals is prepared from 100g of cassia seed, 1500g of curcuma, 2000g of rhizoma alismatis, 500g of notoginseng and 2000g of bermudagrass herb. The quality detection method of the capsule for reducing blood fat and activating collaterals additionally provides thin-layer chromatography identification of the rhizoma alismatis on the basis of the primary standard, and the rhizoma alismatis is one of main components of the capsule. After the thin-layer chromatography identification of the rhizoma alismatis is additionally provided on the basis of the primary standard, the purpose of qualitatively controlling the rhizoma alismatis in the preparation is achieved, the quality detection standard of the capsule for reducing blood fat and activating collaterals is perfected, and simultaneously, a scientific basis for judging the truth of products and controlling the quality of products is provided. In the method, a sample test is simple and convenient to operate; and proven by negative interference and other continuous verification tests, the method has the advantages of negative non-interference, good reproducibility and strong specificity. The invention perfects the quality detection standard and improves the control capability of the product quality.

Description

technical field [0001] The invention relates to the technical field of drug testing, in particular to a quality testing method for Jiangzhi Tongmai capsules. Background technique [0002] Jiangzhitongmai Capsules are composed of cassia seed 100g, turmeric 1500g, Alisma 2000g, Panax notoginseng 500g and iron thread grass 2000g. The preparation method is: crush cassia seeds into fine powder, and set aside; add water to decoct turmeric, Alisma, and iron wire grass for two times, the first time for 2 hours, and the second time for 1 hour, combine the decoctions, filter, and concentrate the filtrate to a relatively high temperature. Clear paste with a density of 1.08-1.13 (75°C), cool to room temperature, add ethanol to precipitate three times (add ethanol each time to make the alcohol content 70% by volume), let stand for 24 hours, filter, take the filtrate and concentrate to form a thick paste , dried, crushed into fine powder, and set aside; Panax notoginseng is crushed into ...

Claims

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Application Information

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IPC IPC(8): A61K36/9066G01N30/02G01N30/90A61P3/06
Inventor 唐秋海
Owner 唐秋海
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