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Quality detection method of Chinese angelica oral liquid for benefiting blood

A quality inspection method, the technology of Yixue Oral Liquid, is applied in blood diseases, measuring devices, pharmaceutical formulas, etc. It can solve problems such as no identification and content determination, too simple control indicators, and inability to control product quality, so as to achieve easy quality control , good reproducibility

Active Publication Date: 2011-08-24
GUIYANG XINTIAN PHARMA CO LTD
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

It is obtained from the modified dosage form of the drug "Danggui Yixue Gao" which has existing national drug standards. The existing quality standard of "Danggui Yixue Gao" only checks the relative density and meets the relevant regulations under the decoction. There is no identification and Content determination and control indicators are too simple to effectively control the quality of the product

Method used

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  • Quality detection method of Chinese angelica oral liquid for benefiting blood
  • Quality detection method of Chinese angelica oral liquid for benefiting blood
  • Quality detection method of Chinese angelica oral liquid for benefiting blood

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preparation example Construction

[0042] 2. Preparation of reference solution

[0043] Preparation of reference substance stock solution: Accurately weigh 12.6 mg of ferulic acid reference substance, put it in a 50ml brown volumetric flask, add 70% methanol solution to dissolve and dilute to the mark, shake well, and obtain a solution containing 0.252mg of reference substance per 1ml.

[0044] Preparation of reference substance solution: Accurately measure 3ml of the above-mentioned ferulic acid reference substance stock solution and put it in a 50ml brown volumetric flask, add 70% methanol solution to dilute to the mark, shake well, and obtain a reference substance solution containing 15.12 μg per 1ml.

[0045] 3. Chromatographic condition selection test

[0046] With reference to "Chinese Pharmacopoeia" 2005 edition, the chromatographic conditions for the determination of the content of Angelica medicinal materials are as follows:

[0047] Chromatographic conditions Chromatographic column: Hypersil ODS2 C18 c...

Embodiment

[0095] The quality detection method of Angelica Yixue Oral Liquid comprises the steps:

[0096] (1) Identification:

[0097]a. Take 50ml of this product, shake and extract 3 times with ether, 30ml each time, combine the ether solution, evaporate to dryness, add 2ml of ethyl acetate to the residue to dissolve, and use it as the test solution; 30ml, heat and reflux for 2 hours, filter, evaporate the filtrate to dryness, add 2ml of ethyl acetate to the residue to dissolve, and use it as the reference medicinal material solution; then take the reference substance of ferulic acid, add ethyl acetate to prepare a solution containing 1mg per 1ml, as Reference substance solution; test according to thin-layer chromatography (Appendix VIB of Chinese Pharmacopoeia in 2005), draw 10 μl of the test solution, 5 μl of the reference substance solution and 5 μl of the reference medicinal material solution, and place them on the same silica gel G thin-layer plate respectively. Petroleum ether (...

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Abstract

The invention discloses a quality detection method of a Chinese angelica oral liquid for benefiting blood, comprising the following steps of: distinguishing: TLC detection of rhizoma ligustici wallichii and white paeony root; content determination: referencing to high performance liquid chromatography: a. chromatographic condition and system applicability test; b. preparation of a reference substance solution; c. preparation of a test substance solution; and d. a determination method. Counted by ferulic acid (C10H10O4), the content of Chinese angelica and the rhizoma ligustici wallichii in each Chinese angelica oral liquid for benefiting blood is not less than 0.30mg. The method has stability and favorable repeatability and is beneficial to controlling the quality of products.

Description

technical field [0001] The invention belongs to the field of quality control of traditional Chinese medicine preparations, in particular to a quality detection method of Angelica Yixue Oral Liquid. Background technique [0002] Angelica Yixue Oral Liquid is composed of Angelica 252.6g, Rehmannia glutinosa 15.75g, Paeoniae Alba (wine) 15.75g, Chuanxiong (wine) 7.875g, Codonopsis 15.75g, Astragalus (honey-roasted) 15.75g, donkey-hide gelatin 7.875g, Poria cocos 15.75g, licorice (honey roasted) 7.875g. For the above nine flavors, add donkey-hide gelatin with appropriate amount of water and heat to dissolve; add water to decoct angelica twice, add 8 times the amount of water for 2 hours for the first time, and decoct for 1 hour with 6 times the amount of water for the second time, combine the decoction, filter , the filtrate is concentrated to a clear paste with a relative density of 1.1-1.2 (55°C); the remaining Qiwei, such as Chuanxiong, is decocted twice with 8 times and 6 t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/36G01N30/90A61K36/804A61P1/14A61P7/06A61K35/36
Inventor 董大伦
Owner GUIYANG XINTIAN PHARMA CO LTD
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