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A detection method of Qianlieping Capsules for treating acute and chronic prostatitis

A chronic prostatitis and detection method technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problem of not formulating other ingredients, achieve the effect of good sample reproducibility, strong specificity, and guaranteed curative effect

Active Publication Date: 2016-01-20
XIAN CHIHO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the existing detection methods for acute and chronic prostatitis drugs, such as Qianlieping Capsules, only Thin Layer Chromatography (TLC) was used to identify Salvia Miltiorrhiza, but no identification method was developed for other ingredients, especially safflower

Method used

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  • A detection method of Qianlieping Capsules for treating acute and chronic prostatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Prescription and preparation method of Qianlieping capsule

[0050] Prescription: Patrinia 702g Salvia 234g Radix Paeoniae Rubra 234g

[0051] 234g peach kernel 234g safflower 234g Zeilan

[0052] Shiwei 234g frankincense 47g myrrh 47g

[0053] Preparation method: the above nine flavors, frankincense and myrrh are crushed into fine powder and set aside. Grind Danshen and Radix Paeoniae Rubra into coarse powder, add ethanol to extract twice, each time for 2 hours, combine the extracts, filter, recover ethanol from the filtrate and concentrate to a thick paste with a relative density of 1.32-1.36 (60°C), and set aside. The rest of Patrinia and other five flavors and the medicinal residue after alcohol extraction are decocted twice, the first time is 2 hours, the second time is 1.5 hours, the decoction is combined, filtered, and the filtrate is concentrated under reduced pressure to a relative density of 1.32-1.36 ( 60°C), add the above-mentioned fine powder...

Embodiment 2

[0055] Example 2 TLC Identification of Safflower in Qianlieping Capsules

[0056] 1. Test conditions: double-layer expansion cylinder (Shanghai Xinyi); silica gel GF 254 (for thin-layer chromatography, Qingdao Ocean Chemical Factory); home-made thin-layer plates with a thickness of 0.3 mm. The rest of the reagents were analytically pure.

[0057] 2. Test procedure: get the contents of 20 capsules prepared in Example 1, grind finely, add ether 50ml, reflux extraction for 30 minutes, filter, the filtrate is evaporated to dryness, and the residue adds 2ml of ethanol to make dissolving, as need testing solution.

[0058] Take another 0.5 g of safflower reference medicinal material, and make a reference medicinal material solution in the same way.

[0059] Then take the negative sample without safflower prepared according to the prescription ratio and process of Qianlieping Capsules, and make a negative reference solution in the same way as the test solution. The prescription ...

Embodiment 3

[0064] Example 3 TLC Identification of Safflower in Qianlieping Capsules

[0065] 1. Test conditions: double-layer expansion cylinder (Shanghai Xinyi); silica gel GF 254 (for thin-layer chromatography, Qingdao Ocean Chemical Factory); home-made thin-layer plates with a thickness of 0.3 mm. The rest of the reagents were analytically pure.

[0066] 2. Test procedure: get the contents of 20 capsules prepared in Example 1, grind finely, add ether 50ml, reflux extraction for 30 minutes, filter, the filtrate is evaporated to dryness, and the residue adds 2ml of ethanol to make dissolving, as need testing solution.

[0067] Take another 0.5 g of safflower reference medicinal material, and make a reference medicinal material solution in the same way.

[0068] Then take the negative sample without safflower prepared according to the prescription ratio and process of Qianlieping Capsules, and make a negative reference solution in the same way as the test solution. The prescription ...

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Abstract

The invention provides a detection method of a Qianlieping capsule for treating acute and chronic prostatitis. The detection method comprises a step that safflower in the above medicine is detected by adopting thin layer chromatography, wherein thin layer chromatography conditions are characterized in that a silica gel GF254 thin layer plate is adopted, and an A-B-C mixed solution having an A / B / C volume ratio of 5-12:1-5:0.1-0.7, preferably 7-11:1-3:0.1-0.5, and more preferably 9:2:0.5 is adopted as a developing solvent; the above A solution is selected from benzene, toluene, cyclohexane, trichloromethane, dichloromethane and n-butanol , and preferably cyclohexane; the above B solution is selected from acetone, ethyl acetate, butyl acetate, methanol and glycol, and preferably ethyl acetate; and the above C solution is selected from water, methyl formate, dimethyl ether, acetate acid gracial and formic acid, and preferably acetate acid gracial. The method allows the quality of the medicine to be effectively controlled, and to be stable, controllable, efficient and safe.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a method for detecting a medicine for treating acute and chronic prostatitis, in particular to a method for detecting capsules for treating acute and chronic prostatitis, such as Qianlieping capsules. Background technique [0002] Prostatitis is a common disease in men, most of which occur in young adults. Clinically, prostatitis can be divided into two types: acute and chronic. Acute prostatitis is rare clinically, and chronic prostatitis is more common in adults, accounting for about 1 / 5 of outpatients in urology department. Because chronic prostatitis is often accompanied by seminal vesiculitis, it is also called prostatic seminal vesiculitis. [0003] The prescription of Qianlieping Capsules (standard number: WS-10459(ZD-0459)-2002, Z20025651) is Patrinia 702g, Salvia miltiorrhiza 234g, Chishao 234g, Peach kernel 234g, Safflower 234g, Eupatorium 234g, Stone Wei ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/90
Inventor 胡小虎赵宗平
Owner XIAN CHIHO PHARMA
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