Application of tuberculosis chemotherapeutic drugs in treatment of psoriasis

A chemotherapeutic drug and psoriasis technology, applied in the field of medicine, can solve the problems of high price, uncorrected treatment, strong toxic and side effects, etc., and achieve the effects of low price, reduced medication time, and reduced economic burden

Inactive Publication Date: 2019-02-01
郭长安
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The purpose of the present invention is to provide a new medical application of tuberculosis chemotherapeutic drugs in order to

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  • Application of tuberculosis chemotherapeutic drugs in treatment of psoriasis
  • Application of tuberculosis chemotherapeutic drugs in treatment of psoriasis
  • Application of tuberculosis chemotherapeutic drugs in treatment of psoriasis

Examples

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example 1

[0059] Lu Chenghong, male, 49 years old, weighing 70kg. History of present illness: erythema and desquamation on the trunk and limbs for 2 years, mild itching, no other obvious symptoms, no cough and fever.

[0060] Physical examination: erythema and papules of about 0.4 × 0.4 cm in size spread all over the trunk and proximal extremities, with clear borders, a lot of desquamation, and easy bleeding after scraping. The characteristics of the skin lesion on the patient's right upper arm were as follows: figure 1 (a) shown.

[0061] Pathological diagnosis: if figure 2 As shown, in the skin of the right upper arm, hemorrhage can be seen in the parakeratotic corneum, the neutrophils gather, the epidermis protrudes regularly, and the chronic inflammatory cell infiltration around the blood vessels in the superficial dermis. Based on the above pathological changes, it is consistent with psoriasis vulgaris.

[0062] Combination regimen:

[0063] Oral isoniazid: 0.2g per day, with...

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Abstract

Belonging to the field of medical technology, the invention discloses a new use of tuberculosis chemotherapeutic drugs, i.e. application of tuberculosis chemotherapeutic drugs in treatment of psoriasis. According to the invention, through oral administration of isoniazide, rifampicin, and any one of the antitubercular drugs sodium aminosalicylate, pyrazinamide, ethambutol, moxifloxacin hydrochloride and levofloxacin hydrochloride by psoriasis patients, 95% or more of the psoriasis patients can have obviously alleviated symptoms in 6-10 weeks and can achieve recovery in 10-18 weeks, and after recovery, the consolidation therapy to the 28th week is a treatment cycle, and relapse hardly occurs, thus reaching the purpose of radical treatment of psoriasis. If psoriasis is caused by mycobacterium tuberculosis infection, the invention starts from the cause of psoriasis, completely changes the treatment concept of original psoriasis treatment drugs and achieves etiological treatment. Moreover,the tuberculosis chemotherapeutic drugs involved in the invention are cheap, thus alleviating the psoriasis patients' economic burden caused by long-term medication of psoriasis patients.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of tuberculosis chemotherapeutic drugs in the treatment of psoriasis, in particular to the application of tuberculosis chemotherapeutic drugs in combination in the treatment of psoriasis. Background technique [0002] Psoriasis is a common chronic relapsing inflammatory skin disease. The course of the disease is relatively long, and it cannot be completely cured at present. As an erythematosquamous skin disease, it often causes damage to the appearance of patients, and seriously affects the quality of life and even physical and mental health of patients. In the later stage of the disease, it is very likely to damage the patient's joints and multiple internal organs, posing a great threat to the patient's life and health. [0003] The current literature shows that the etiology of psoriasis is still unclear, and it is generally believed that it is mainly mediated...

Claims

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Application Information

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IPC IPC(8): A61K31/4409A61K31/496A61K31/606A61K31/4965A61K31/133A61K31/4709A61K31/5383A61P17/06A61P31/06
CPCA61K31/133A61K31/4409A61K31/4709A61K31/496A61K31/4965A61K31/5383A61K31/606A61P17/06A61P31/06A61K2300/00
Inventor 郭长安汪文杰白东江刘宏斌于建平
Owner 郭长安
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