Preparation method of curcumin-loaded structured lipid based nano emulsion

A technology of structural lipids and curcumin, applied in the direction of food science, etc., can solve the problems of less than 40% bioavailability, insolubility in water, and limited application, so as to improve bioavailability, good emulsion stability, and improve poor water solubility Effect

Inactive Publication Date: 2019-02-12
NANJING UNIV OF FINANCE & ECONOMICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But curcumin also has certain shortcomings, insoluble in water, poor absorption, low bioavailability (less than 10%), instability, fast metabolism, easy degradation, etc., which limit its application
[0003] In the prior art, some researchers

Method used

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  • Preparation method of curcumin-loaded structured lipid based nano emulsion
  • Preparation method of curcumin-loaded structured lipid based nano emulsion
  • Preparation method of curcumin-loaded structured lipid based nano emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A preparation method of a structured lipid-based nanoemulsion loaded with curcumin, comprising the following steps:

[0041] (1) Preparation of structured lipids: Mix rapeseed oil and coconut oil in a molar ratio of 1:1, add immobilized lipase RM-IM accounting for 8% of the total weight of rapeseed oil and coconut oil and rapeseed oil Water with 0.96% of the total weight of coconut oil is placed in a 40°C constant temperature water bath shaker for 12 hours of shaking reaction. The shaking frequency should be able to fully shake the mixture of enzyme and oil. The product is separated and purified, and free fatty acids and monoglycerides are removed by molecular distillation to obtain structured lipids;

[0042] (2) The construction of structured lipid-based nanocarriers: add curcumin of 1% of structured lipid weight to the structured lipid prepared in step (1), and use it as the oil phase after mixing; Tween 80 with 3% pure water weight is used as the water phase; the o...

Embodiment 2

[0046] A preparation method of a structured lipid-based nanoemulsion loaded with curcumin, comprising the following steps:

[0047] (1) Preparation of structured lipids: Mix rapeseed oil and coconut oil in a molar ratio of 1:1, add immobilized lipase RM-IM accounting for 8% of the total weight of rapeseed oil and coconut oil and rapeseed oil Water with 0.96% of the total weight of coconut oil is placed in a 40°C constant temperature water bath shaker for 12 hours of shaking reaction. The shaking frequency should be able to fully shake the mixture of enzyme and oil. The product is separated and purified, and free fatty acids and monoglycerides are removed by molecular distillation to obtain structured lipids;

[0048] (2) The construction of structured lipid-based nanocarriers: add curcumin of 1% of structured lipid weight to the structured lipid prepared in step (1), and use it as the oil phase after mixing; Tween 80 with 3% pure water weight is used as the water phase; the o...

Embodiment 3

[0052] A preparation method of a structured lipid-based nanoemulsion loaded with curcumin, comprising the following steps:

[0053] (1) Preparation of structured lipids: Mix rapeseed oil and coconut oil in a molar ratio of 1:1, add immobilized lipase RM-IM accounting for 8% of the total weight of rapeseed oil and coconut oil and rapeseed oil Water with 0.96% of the total weight of coconut oil is placed in a 40°C constant temperature water bath shaker for 12 hours of shaking reaction. The shaking frequency should be able to fully shake the mixture of enzyme and oil. The product is separated and purified, and free fatty acids and monoglycerides are removed by molecular distillation to obtain structured lipids;

[0054] (2) The construction of structured lipid-based nanocarriers: add curcumin of 1% of structured lipid weight to the structured lipid prepared in step (1), and use it as the oil phase after mixing; Tween 80 with 3% pure water weight is used as the water phase; the o...

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PUM

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Abstract

The invention provides a preparation method of curcumin-loaded structured lipid based nano emulsion which comprises the steps: firstly, preparing medium-long carbon chain structured lipid from rapeseed oil and coconut oil under the catalysis of RM-IM lipase; then dissolving liposoluble curcumin into the synthesized structured lipid to serve as an oil phase, dissolving Tween 80 into ultrapure waterto serve as a water phase and mixing the oil phase and the water phase; finally, utilizing a high-speed disperser to pre-disperse a mixture and utilizing an ultrasonic probe to prepare an obtained product into even nano emulsion under high pressure homogenization. The nano emulsion prepared by the preparation method disclosed by the invention can improve the biological yield of the curcumin, further has the characteristics of strong stability, easiness in digestion and the like and can serve as functional food to be eaten.

Description

technical field [0001] The invention relates to a preparation method of a structured lipid-based nanoemulsion loaded with curcumin, belonging to the technical field of food bioprocessing. Background technique [0002] Curcumin is a phenolic substance extracted from the rhizome of turmeric, which has various pharmacological effects such as anti-inflammation, anti-tumor, anti-oxidation, lowering blood fat, improving the body's immunity, anti-bacterial, and preventing and treating Alzheimer's disease. potential for clinical application. But curcumin also has certain shortcomings, such as insoluble in water, poor absorption, low bioavailability (less than 10%), instability, fast metabolism, easy degradation, etc., which limit its application. [0003] In the prior art, some researchers used proteins, carbohydrates, etc. as wall materials to wrap curcumin to improve its bioavailability. After being wrapped by wall materials, the bioavailability of curcumin was improved, but the ...

Claims

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Application Information

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IPC IPC(8): A23L33/105A23L29/10
CPCA23L29/10A23L33/105A23V2002/00
Inventor 鞠兴荣吴进王立峰徐斐然熊文飞季圣阳
Owner NANJING UNIV OF FINANCE & ECONOMICS
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