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Medical application of 7-aromadendrene-6-ketone or 4-aromadendrene in field of gynaecology

A kind of fumerene, gynecological tumor technology, applied in gynecology, medicine, 7-fumerene-6-one or 4-fumerene in the field of gynecology, can solve the problems of death, derivation and the like

Inactive Publication Date: 2019-02-12
淮安培元基因科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although complete remission can be achieved after initial surgery and chemotherapy, most patients with advanced disease will still relapse within 2 to 3 years, and eventually become resistant to chemotherapy and die

Method used

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  • Medical application of 7-aromadendrene-6-ketone or 4-aromadendrene in field of gynaecology
  • Medical application of 7-aromadendrene-6-ketone or 4-aromadendrene in field of gynaecology

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Experimental program
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Embodiment Construction

[0015] The substantive content of the present invention will be described in detail below in conjunction with the embodiments, but the protection scope of the present invention is not limited thereto.

[0016] 1. Experimental materials

[0017] The structural formula of the test compound is as figure 1 As shown, including trumpetene, trumpet alcohol, cinnamonolide, isoartemisinic acid, 7-armentene-6-one and 4-arrene, the standard products are purchased or self-made, and the purity is ≥98%.

[0018] Human ovarian cancer SKOV3 cells and human cervical cancer Hela cells were purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences.

[0019] DMEM / F12 medium, high-glucose DMEM medium, and fetal bovine serum were purchased from GIBCO.

[0020] Tetramethylazolazolium blue (MTT) and DMSO were purchased from SIGMA.

[0021] Double antibody solution and trypsin were purchased from Hyclone Company, USA.

[0022] 2. Experimental method

[0023] 1. Cell culture

[002...

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Abstract

The invention discloses medical application of 7-aromadendrene-6-ketone or 4-aromadendrene in the field of gynaecology. The invention discovers that gweicurculactone, isorupestonic acid, 7-aromadendrene-6-ketone and 4-aromadendrene have an excellent proliferation inhibition effect on human ovarian cancer SKOV3 cells and human cervical cancer Hela cells; despite that ledene is a dehydrated productof ledol in chemical structure, and has a relatively similar chemical structure, ledene shows great difference in the proliferation inhibition activity on the human ovarian cancer SKOV3 cells and human cervical cancer Hela cells, wherein the ledene realizes an obvious proliferation inhibition effect on the human cervical cancer Hela cells but an unapparent proliferation inhibition effect on the human ovarian cancer SKOV3 cells, while the ledol realizes an obvious proliferation inhibition effect on the human ovarian cancer SKOV3 cells but an unapparent proliferation inhibition effect on the human cervical cancer Hela cells. The ledene, the ledol, the gweicurculactone, the isorupestonic acid, the 7-aromadendrene-6-ketone and the 4-aromadendrene all can be used for treating gynecological tumors.

Description

technical field [0001] The invention belongs to the field of medicine and relates to gynecology, in particular to a medical application of 7-omanrene-6-one or 4-omanrene in the field of gynecology. Background technique [0002] Gynecological tumor is a common and frequently-occurring disease that seriously threatens women's health, and can be divided into benign and malignant. Common gynecological benign tumors include ovarian benign tumors, ovarian tumor-like lesions (simple ovarian cysts and ovarian chocolate cysts, etc.), pelvic inflammatory masses, adenomyosis, and uterine fibroids. The specific methods include surgery, drugs, intervention, etc., among which surgery is the main treatment method, but its damage to ovarian function has been in recent years. has been gradually paid attention to. Traditional Chinese medicine treatment of gynecological benign tumors can control and reduce the tumor size for patients who do not meet the surgical indications, so as to avoid s...

Claims

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Application Information

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IPC IPC(8): A61K31/015A61K31/045A61K31/122A61K31/19A61K31/365A61P35/00
CPCA61K31/015A61K31/045A61K31/122A61K31/19A61K31/365A61P35/00
Inventor 张长林杨佳
Owner 淮安培元基因科技有限公司
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