Application of esculentoside A in reducing blood glucose

A pokeweed saponin A and hypoglycemic technology, applied in the field of medicine, can solve the problems of reduced insulin effect and cells unable to respond to it

Inactive Publication Date: 2019-03-08
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Type 2 diabetes is also called non-insulin-dependent diabetes, which accounts for more than 90% of diabetic patients. It is chara

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  • Application of esculentoside A in reducing blood glucose
  • Application of esculentoside A in reducing blood glucose
  • Application of esculentoside A in reducing blood glucose

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Experimental program
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Embodiment Construction

[0015] The present invention is described in further detail below:

[0016] Application of pokeweed saponin A in hypoglycemia.

[0017] The concentration of pokeweed saponin A administered to hyperglycemic mice is 0.100 mg / ml-0.200 mg / ml.

[0018] The dose of pokeweed saponin A in hyperglycemic mice is 0.05 mg / g-0.10 mg / g / day.

[0019] The dose of pokeweed saponin A used in hyperglycemia population is 2mg / kg-8mg / kg.

[0020] The purity of the pokeweed saponin A is 85%-98%.

[0021] The drinking method of the pokeweed saponin A is gavage or oral administration.

[0022] Animal experiment: Kunming Zhong mice were used, weighing about 25g, and four test groups were set up: blank control group, hyperglycemia mouse model group, metformin drug group, and pokeweed saponin A drug group. The concrete implementation mode of four test groups is as follows:

[0023] Experimental group-blank control group: Mice were fed normally, neither hyperglycemia model nor other drugs were admini...

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Abstract

The invention discloses application of esculentoside A in reducing blood glucose. According to the application disclosed by the invention, an STZ high blood glucose mouse model is established to inspect a blood glucose reducing effect of the esculentoside on high blood glucose mice. An empty-stomach mouse gavage method is used for the esculentoside, and a tail-amputation blood taking blood glucosemeter detection method is used for blood glucose level detection. A blank control group, an esculentoside standard substance experimental group, an esculentoside extractive group in which molding andgavage are performed at the same time, a mouse high blood glucose model group and a melbine experimental group are arranged. Four indexes of weight, water intake, food intake and blood glucose levelare observed. The dosage range of the esculentoside is 0.100 mg/ml to 0.200 mg/ml. After the esculentoside is applied to gavage, the blood glucose level of the high blood glucose mice is reduced to the range between 6.7 to 10.9 from the range between 11.0 and 25.0 within 28 days; thus, a blood glucose reducing effect is obvious. Furthermore, the esculentoside can obviously improve the situations of peeing more, eating more, drinking more and less weight.

Description

technical field [0001] The invention relates to a new application of pokeweed saponin A with hypoglycemic effect, and belongs to the technical field of medicine. Background technique [0002] Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by defective insulin secretion or impaired biological action, or both. The long-term high blood sugar in diabetes leads to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. The onset of diabetes has the symptoms of "three excesses and one deficiency", that is, excessive urination, excessive drinking, excessive eating and low body weight. [0003] Diabetes can be divided into type Ⅰ diabetes and type Ⅱ diabetes according to different pathogenesis. Type 1 diabetes accounts for less than 10% of diabetes, and is mainly dependent on insulin treatment. More than 80% of pancreatic islet B cells in type 1 diabetes are destroyed, ma...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P3/10
CPCA61K31/704A61P3/10
Inventor 吕艳春
Owner ZUNYI MEDICAL UNIVERSITY
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