Compound traditional Chinese medicine composition for preventing and treating disturbance of coronary microcirculation and animal experiment method

A microcirculation disorder and compound Chinese medicine technology, applied in the field of traditional Chinese medicine, can solve the problems that the research is not yet supported by large-scale evidence-based medicine

Inactive Publication Date: 2019-03-19
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no large-scale evidence-based medical evidence to support the current research

Method used

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  • Compound traditional Chinese medicine composition for preventing and treating disturbance of coronary microcirculation and animal experiment method
  • Compound traditional Chinese medicine composition for preventing and treating disturbance of coronary microcirculation and animal experiment method
  • Compound traditional Chinese medicine composition for preventing and treating disturbance of coronary microcirculation and animal experiment method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] According to the weight ratio of each component, the traditional Chinese medicine takes 48 grams of astragalus, 26 grams of angelica, 11 grams of scorpion, and 15 grams of centipede. Add 10 times the amount of water for the first time and decoct with a slow fire for 50 minutes, add 6 times the amount of water for the third time and decoct with a slow fire for 30 minutes, combine the three decoctions, filter through gauze, and concentrate in a water bath at 100°C to 150 ml. Store in a refrigerator at 4°C, that is, the finished product.

[0089] The animal experiment method of the compound Chinese medicine composition of a kind of prevention and treatment of coronary microcirculation disorder:

[0090] 1. Experimental process:

[0091] (1) Experimental animals:

[0092] Select 90 male SD rats with a body weight of (240 ± 20) grams, SPF grade, provided by Liaoning Changsheng Biotechnology Co., Ltd. (permit number: SYXK (Liao) 2013-0009);

[0093] (2) Drugs and reagents:...

Embodiment 2

[0141] According to the weight ratio of each component, the traditional Chinese medicine takes 50 grams of astragalus, 24 grams of angelica, 12 grams of scorpion, and 14 grams of centipede. After soaking in 15 times the amount of water for 40 minutes, decoct for 70 minutes at 1 fire for the first time. Add 10 times the amount of water for the first time and decoct with a slow fire for 50 minutes, add 6 times the amount of water for the third time and decoct with a slow fire for 30 minutes, combine the three decoctions, filter through gauze, and concentrate in a water bath at 100°C to 150 ml. Store in a refrigerator at 4°C, that is, the finished product.

Embodiment 3

[0143] According to the weight ratio of each component, the traditional Chinese medicine takes 51 grams of astragalus, 23 grams of angelica, 10 grams of scorpion, and 16 grams of centipede. After soaking in 15 times the amount of water for 40 minutes, decocting for 70 minutes at 1 fire for the first time, and 70 minutes at the second time. Add 10 times the amount of water for the first time and decoct with a slow fire for 50 minutes, add 6 times the amount of water for the third time and decoct with a slow fire for 30 minutes, combine the three decoctions, filter through gauze, and concentrate in a water bath at 100°C to 150 ml. Store in a refrigerator at 4°C, that is, the finished product.

[0144] A clinical trial report of a compound traditional Chinese medicine composition for preventing and treating coronary microcirculation disorder:

[0145] 1. Clinical trial report 1

[0146] (1) Drug formulations used in clinical trials

[0147] Astragalus 48-52%, Angelica 23-27%, S...

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Abstract

The invention relates to a compound traditional Chinese medicine composition for preventing and treating the disturbance of coronary microcirculation and an animal experiment method. The compound traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: radix astragali, angelica, scorpio and scolopendra. The preparation method of thecompound traditional Chinese medicine composition comprises the following steps: preparing the traditional Chinese medicines in parts by weight: radix astragali, angelica, scorpio and scolopendra, soaking the traditional Chinese medicines into water which is 15 times of the total weight of the traditional Chinese medicines for 40 minutes, carrying out decoction with strong fire for 70 minutes forthe first time, adding water which is 10 times of the total weight of the traditional Chinese medicines, carrying out decoction with soft fire for 50 minutes for the second time, adding water which is6 times of the total weight of the traditional Chinese medicines, carrying out decoction with soft fire for 50 minutes for the third time, combining three decoction solutions, filtering by virtue ofgauze, concentrating to 150ml through water bath at 100 DEG C, and storing the combined decoction solution in a refrigerator at 4 DEG C, so as to obtain the finished product. The compound traditionalChinese medicine composition has the efficacies of expanding blood vessels, inhibiting platelet aggregation and inflammation and the like, is capable of improving the disturbance of coronary microcirculation and can be applied to the technical field of the traditional Chinese medicine.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine composition for preventing and treating coronary microcirculation disorder and an animal experiment method in the technical field of traditional Chinese medicine. Background technique [0002] Currently, about 40% of chest pain symptoms are considered to be coronary microcirculation disorder (CMD for short), which shows that coronary microcirculation disorder plays an important role in the diagnosis, treatment and prognosis of ischemic heart disease. The normal and smooth operation of coronary microcirculation ensures the exchange of substances and nutrients between cardiomyocytes so that they can exert normal physiological functions. Therefore, more and more attention is paid to the blood perfusion level of myocardial microcirculation, so how to maintain the continuous blood supply of blood vessels and minimize the necrosis caused by ischemia is of great scientific significance and neces...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K49/00A61P9/10G01N33/543A61K35/646A61K35/648
CPCA61K35/646A61K35/648A61K36/232A61K36/481A61K49/0008A61K2236/331A61K2236/39A61P9/10G01N33/543A61K2300/00
Inventor 宫丽鸿
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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