A kind of kaolin reagent quality control product and its preparation method and application

A quality control material, kaolin technology, applied in the preparation of test samples, biological testing, material inspection products, etc., can solve the problems of low stability, accuracy and safety, achieve high accuracy, good uniformity, The effect of improving accuracy

Active Publication Date: 2022-06-14
中科精瓒(武汉)医疗技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Therefore, the technical problem to be solved by the present invention is to overcome the defects of low stability, accuracy and safety of the kaolin reagent used for thromboelastography detection in the prior art, thereby providing a quality control with good accuracy, stability and Kaolin reagent quality control product with high safety

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  • A kind of kaolin reagent quality control product and its preparation method and application
  • A kind of kaolin reagent quality control product and its preparation method and application
  • A kind of kaolin reagent quality control product and its preparation method and application

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Embodiment 1

[0063] The present embodiment provides a method for preparing a kaolin reagent quality control, comprising the following steps:

[0064] S1, preparation of platelet-deficient animal plasma

[0065] S11, weighed 3.8g of sodium citrate dihydrate, dissolved in 80mL distilled water to prepare an aqueous solution of 3.8wt% sodium citrate, placed in a plastic container cup with a total volume of 1000mL.

[0066] Take 800mL of whole blood from at least one of the animals in cattle, sheep, pigs, rabbits and horses and add it to an aqueous sodium citrate solution. When taking blood, it is necessary to gently shake the container cup clockwise or counterclockwise to ensure that the whole blood of the animal is mixed evenly with the aqueous sodium citrate solution, and the time from blood collection to the addition of the aqueous sodium citrate solution should be as short as possible to avoid the blood from coagulating after encountering air.

[0067] After blood collection, seal the containe...

Embodiment 2

[0079] The present embodiment provides a method for preparing a kaolin reagent quality control, comprising the following steps:

[0080] S1, preparation of platelet-deficient animal plasma

[0081] S11, weighed 3.8g of sodium citrate dihydrate, dissolved in 80mL distilled water to prepare an aqueous solution of 3.8wt% sodium citrate, placed in a plastic container cup with a total volume of 1000mL.

[0082] Take 800mL of whole blood from at least one of the animals in cattle, sheep, pigs, rabbits and horses and add it to an aqueous sodium citrate solution. When taking blood, it is necessary to gently shake the container cup clockwise or counterclockwise to ensure that the whole blood of the animal is mixed evenly with the aqueous sodium citrate solution, and the time from blood collection to the addition of the aqueous sodium citrate solution should be as short as possible to avoid the blood from coagulating after encountering air.

[0083] After blood collection, the container cup...

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Abstract

The invention discloses a kaolin reagent quality control product. The quality control product is a freeze-dried preparation, and the raw material of the freeze-dry preparation includes platelet-deficient animal plasma; the R value of the quality control product is 6-8 min, and the K value is 2-5 min. The Angle value is 60°-80°, and the MA value is 23-45mm. The quality control product of kaolin reagent is sensitive to the reaction of kaolin reagent, the accuracy of quality detection is high, and it meets the quality control requirements of kaolin preparation in thromboelastography detection. The quality control product has good reconstitution stability and can be stored for a long time under low temperature conditions. The quality control products are made of animal plasma, which reduces the cost of quality control and improves the safety of quality control operations. The invention also discloses a preparation method of a kaolin reagent quality control product, which can prepare the above-mentioned kaolin reagent quality control product with accurate detection results and good stability. The above-mentioned preparation method is stable and reliable, and the preparation process is simple and easy to operate. In the production and application of kaolin reagent quality control products.

Description

Technical field [0001] The present invention relates to the control standard field of coagulation detection, specifically to a kaolin reagent quality control and preparation method and application thereof. Background [0002] Coagulation is a very complex physiological and biochemical cascade, the essence of which is through a series of enzymatic reactions. The coagulation process is gradually involved by coagulation factors and can be divided into three stages: the formation of prothrombin activators, the activation of prothrombin and the production of fibrin. The evaluation of coagulation function is of great significance for the diagnosis, treatment and prognosis of many diseases, and can not only be used for screening and auxiliary diagnosis of bleeding diseases, but also for predicting or risk assessment of thrombotic diseases; Coagulation factor deficiency and vascular hemophilia can also be diagnosed, guided, and prognostically judged. Coagulation tests are also used to sc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/96G01N33/86G01N1/28
CPCG01N1/28G01N33/86G01N33/96G01N2001/2893
Inventor 杨语谌周国熠沈海洲
Owner 中科精瓒(武汉)医疗技术有限公司
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