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A kind of synthetic method of furoate compound

A synthesis method and compound technology, applied in organic chemistry and other directions, can solve the problems of inconvenient operation, strong acid pollution, high price of precious metals, etc., and achieve the effects of high production efficiency, environmental friendliness and low cost.

Active Publication Date: 2021-06-25
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, furoic acid ester compounds are mainly obtained by direct esterification of furoic acid and alcohol, and this method usually requires strong acid as a catalyst to be carried out under high temperature conditions, strong acid will bring pollution, and high temperature will bring inconvenience to the operation
However, the current reports on the one-step synthesis of furoate compounds directly from furfural and alcohol have the problems of high price of noble metals, difficulty in recovery of homogeneous base, or complex catalyst preparation process.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Add 1.15mmol furfural, 100mmol methanol and 0.30g ammonium persulfate into a 50mL round-bottomed flask, and react under reflux at 60°C for 4h. After the reaction, water is added to the reaction system to dissolve the oxidant ammonium persulfate, and then liquid-liquid separation is carried out, and the liquid phase product containing methyl furoate is taken for detection. After gas chromatography analysis, the yield of methyl furoate was 26.4%.

Embodiment 2

[0024] Add 1.43mmol of furfural, 100mmol of ethanol and 0.25g of ammonium persulfate into a 50mL round bottom flask, and react under reflux at 60°C for 5h. After the reaction, water is added to the reaction system to dissolve the oxidant ammonium persulfate, and then liquid-liquid separation is carried out, and the liquid phase product containing ethyl furoate is taken for detection. After analysis by gas chromatography, the yield of ethyl furoate was 36.0%.

Embodiment 3

[0026] Add 1.04mmol furfural, 50mmol ethanol and 0.20g ammonium persulfate into a 50mL round-bottomed flask, and react under reflux at 60°C for 3h. After the reaction, water is added to the reaction system to dissolve the oxidant ammonium persulfate, and then liquid-liquid separation is carried out, and the liquid phase product containing ethyl furoate is taken for detection. After gas chromatography analysis, the yield of ethyl furoate was 17.8%.

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PUM

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Abstract

The invention discloses a synthesis method of furoate compounds, which comprises the following steps: adding furfural, a solvent and an oxidizing agent into a container, stirring at a certain temperature for reaction; after the reaction, adding water into the reaction system to dissolve the oxidizing agent , and then perform liquid-liquid separation to collect the liquid phase products containing furoate compounds. The method has mild reaction conditions, does not need strong acid as a catalyst, and furfural is oxidized and esterified in one step to obtain furoate compounds, and has simple operation, low cost, and is environmentally friendly.

Description

technical field [0001] The invention relates to a method for synthesizing furoate compounds, belonging to the technical field of energy and chemical industry. Background technique [0002] Furoate compounds are an important class of edible spices, which naturally exist in foods such as roasted almonds, roasted coffee, and kiwi. The synthetic furoate compounds can also be used as flavor modifiers and flavor enhancers in food, beverage and cosmetic industries. Thirteen furoate compounds have been approved as spices in foreign countries. [0003] At present, furoic acid ester compounds are mainly obtained by direct esterification of furoic acid and alcohol, and this method usually requires strong acid as a catalyst to be carried out under high temperature conditions, strong acid will bring pollution, and high temperature will bring inconvenience to the operation . However, the current reports on the one-step synthesis of furoate compounds directly from furfural and alcohol h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/68
CPCC07D307/68
Inventor 曾宪海高哲邦冯云超王婷孙勇唐兴林鹿
Owner XIAMEN UNIV